Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance
This review addresses the concept of ontogenetic origin of health and disease (DOHaD) and the new concept of paternal origin of health and disease (POHaD). These concepts are based on scientific evidence that environmental factors impacting mother or father can play a role in reprogramming the healt...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2020-01-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/601 |
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| author | O. V. Sergeyev A. I. Nikitin |
| author_facet | O. V. Sergeyev A. I. Nikitin |
| author_sort | O. V. Sergeyev |
| collection | DOAJ |
| description | This review addresses the concept of ontogenetic origin of health and disease (DOHaD) and the new concept of paternal origin of health and disease (POHaD). These concepts are based on scientific evidence that environmental factors impacting mother or father can play a role in reprogramming the health of their off springs throughout their life span. Moreover, the changes that have arisen can be transmitted through generations via diverse epigenetic mechanisms. Terms, such as epigenetics (a kind of “driver” for these concepts), epigenetic inheritance (including Intergenerational Inheritance – from generation to the next generation and Transgenerational Inheritance – through generations), epigenetic changes caused by the environment (Environmental Epigenetics) are discussed. Vulnerable periods towards epigenetic changes (Windows of Susceptibility) that occur in male germ cells responsible for epigenetic inheritance are considered. Epigenetic epidemiological studies in the field of reproductology are described; their advantages and disadvantages are discussed. These studies can serve as the basis for obtaining new knowledge about the causes of epigenetic variations in germ cells that occur in health and upon exposure to environmental factors as well as the inherited phenotypic outcomes. |
| format | Article |
| id | doaj-art-2e8a33c256e94750afc1b3dd1fe57f22 |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2020-01-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-2e8a33c256e94750afc1b3dd1fe57f222025-08-20T03:19:14ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942020-01-0113432633610.17749/2313-7347.2019.13.4.326-336524Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritanceO. V. Sergeyev0A. I. Nikitin1A.N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State UniversityBaltic Institute of Human ReproductionThis review addresses the concept of ontogenetic origin of health and disease (DOHaD) and the new concept of paternal origin of health and disease (POHaD). These concepts are based on scientific evidence that environmental factors impacting mother or father can play a role in reprogramming the health of their off springs throughout their life span. Moreover, the changes that have arisen can be transmitted through generations via diverse epigenetic mechanisms. Terms, such as epigenetics (a kind of “driver” for these concepts), epigenetic inheritance (including Intergenerational Inheritance – from generation to the next generation and Transgenerational Inheritance – through generations), epigenetic changes caused by the environment (Environmental Epigenetics) are discussed. Vulnerable periods towards epigenetic changes (Windows of Susceptibility) that occur in male germ cells responsible for epigenetic inheritance are considered. Epigenetic epidemiological studies in the field of reproductology are described; their advantages and disadvantages are discussed. These studies can serve as the basis for obtaining new knowledge about the causes of epigenetic variations in germ cells that occur in health and upon exposure to environmental factors as well as the inherited phenotypic outcomes.https://www.gynecology.su/jour/article/view/601periods of vulnerabilitygerm cellsenvironmentepigenetic inheritanceepigenetic epidemiologydohadpohad |
| spellingShingle | O. V. Sergeyev A. I. Nikitin Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance Акушерство, гинекология и репродукция periods of vulnerability germ cells environment epigenetic inheritance epigenetic epidemiology dohad pohad |
| title | Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance |
| title_full | Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance |
| title_fullStr | Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance |
| title_full_unstemmed | Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance |
| title_short | Developmental origins of health and disease (DOHaD) and paternal origins of health and disease (POHaD). Multigenerational inheritance |
| title_sort | developmental origins of health and disease dohad and paternal origins of health and disease pohad multigenerational inheritance |
| topic | periods of vulnerability germ cells environment epigenetic inheritance epigenetic epidemiology dohad pohad |
| url | https://www.gynecology.su/jour/article/view/601 |
| work_keys_str_mv | AT ovsergeyev developmentaloriginsofhealthanddiseasedohadandpaternaloriginsofhealthanddiseasepohadmultigenerationalinheritance AT ainikitin developmentaloriginsofhealthanddiseasedohadandpaternaloriginsofhealthanddiseasepohadmultigenerationalinheritance |