CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei
Mucinous carcinomas arising within an ovarian dermoid tumor are rare. Most of the cases reported in the literature show morphological features resembling an appendiceal mucinous neoplasm. They exhibit CK7-/CK20+ immunophenotype similar to carcinomas of the lower gastrointestinal tract. In this repor...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_1255_21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849732067590406144 |
|---|---|
| author | Amit K. Adhya Abhitesh Singh Dillip K. Muduly Biswajit Sahoo |
| author_facet | Amit K. Adhya Abhitesh Singh Dillip K. Muduly Biswajit Sahoo |
| author_sort | Amit K. Adhya |
| collection | DOAJ |
| description | Mucinous carcinomas arising within an ovarian dermoid tumor are rare. Most of the cases reported in the literature show morphological features resembling an appendiceal mucinous neoplasm. They exhibit CK7-/CK20+ immunophenotype similar to carcinomas of the lower gastrointestinal tract. In this report, we have described a case of a well-differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma-like areas, proliferative/borderline areas, villous adenoma-like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+/CK20+/CDX2 + immunoprofile making it immunohistochemically indistinguishable from a primary ovarian mucinous neoplasm or a metastatic mucinous carcinoma of the lower gastrointestinal tract. |
| format | Article |
| id | doaj-art-2e8702dea24f4910965aa73ccd4b9393 |
| institution | DOAJ |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-2e8702dea24f4910965aa73ccd4b93932025-08-20T03:08:21ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-01-0168118318910.4103/ijpm.ijpm_1255_21CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritoneiAmit K. AdhyaAbhitesh SinghDillip K. MudulyBiswajit SahooMucinous carcinomas arising within an ovarian dermoid tumor are rare. Most of the cases reported in the literature show morphological features resembling an appendiceal mucinous neoplasm. They exhibit CK7-/CK20+ immunophenotype similar to carcinomas of the lower gastrointestinal tract. In this report, we have described a case of a well-differentiated mucinous carcinoma arising within a mature cystic teratoma. The mucinous carcinoma showed a spectrum of morphological patterns, including cystadenoma-like areas, proliferative/borderline areas, villous adenoma-like areas, and areas of invasive carcinoma. In addition, our case showed some unusual findings, namely, diffuse CK7 positivity, associated pseudomyxoma peritonei, and metastasis to lungs. These features were not demonstrated in any of the previously reported cases. Our case shows that the teratomatous mucinous neoplasm of the ovary may show CK7+/CK20+/CDX2 + immunoprofile making it immunohistochemically indistinguishable from a primary ovarian mucinous neoplasm or a metastatic mucinous carcinoma of the lower gastrointestinal tract.https://journals.lww.com/10.4103/ijpm.ijpm_1255_21cdx2ck7ck20mature teratomateratomatous mucinous carcinoma |
| spellingShingle | Amit K. Adhya Abhitesh Singh Dillip K. Muduly Biswajit Sahoo CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei Indian Journal of Pathology and Microbiology cdx2 ck7 ck20 mature teratoma teratomatous mucinous carcinoma |
| title | CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei |
| title_full | CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei |
| title_fullStr | CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei |
| title_full_unstemmed | CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei |
| title_short | CK7+/CK20+/CDX2+ mucinous carcinoma, arising in a mature cystic teratoma of ovary, presenting with disseminated metastasis and pseudomyxoma peritonei |
| title_sort | ck7 ck20 cdx2 mucinous carcinoma arising in a mature cystic teratoma of ovary presenting with disseminated metastasis and pseudomyxoma peritonei |
| topic | cdx2 ck7 ck20 mature teratoma teratomatous mucinous carcinoma |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_1255_21 |
| work_keys_str_mv | AT amitkadhya ck7ck20cdx2mucinouscarcinomaarisinginamaturecysticteratomaofovarypresentingwithdisseminatedmetastasisandpseudomyxomaperitonei AT abhiteshsingh ck7ck20cdx2mucinouscarcinomaarisinginamaturecysticteratomaofovarypresentingwithdisseminatedmetastasisandpseudomyxomaperitonei AT dillipkmuduly ck7ck20cdx2mucinouscarcinomaarisinginamaturecysticteratomaofovarypresentingwithdisseminatedmetastasisandpseudomyxomaperitonei AT biswajitsahoo ck7ck20cdx2mucinouscarcinomaarisinginamaturecysticteratomaofovarypresentingwithdisseminatedmetastasisandpseudomyxomaperitonei |