Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report
Systemic vasculitides (SVs) are characterized by inflammation of the blood vessels wall; the spectrum of their clinical manifestations depends on the type, extent, and location of affected vessels and the activity of systemic inflammation. The etiology of most primary SVs is unknown. Antineutrophil...
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| Language: | Russian |
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IMA-PRESS LLC
2014-12-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/574 |
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| author | Gulazyk Malikovna Koilubaeva R. I. Rudenko Z. A. Abdulkadyrova V. T. Eralieva |
| author_facet | Gulazyk Malikovna Koilubaeva R. I. Rudenko Z. A. Abdulkadyrova V. T. Eralieva |
| author_sort | Gulazyk Malikovna Koilubaeva |
| collection | DOAJ |
| description | Systemic vasculitides (SVs) are characterized by inflammation of the blood vessels wall; the spectrum of their clinical manifestations depends on the type, extent, and location of affected vessels and the activity of systemic inflammation. The etiology of most primary SVs is unknown. Antineutrophil cytoplasmic antibodies (ANCAs) are implicated in its pathogenesis. The presence of ANCAa in patients' serum and the correlation of their level with the severity of clinical manifestations served as a basis for identifying a subgroup of systemic necrotizing vasculitides associated with ANCA synthesis: granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and Churg – Strauss syndrome. GPA is characterized by systemic granulomatous necrotizing vasculitis involving the small vessels of the upper respiratory tract, lung, and kidney.The paper describes a case of difficult diagnosis and successful rituximab (RTM) treatment of generalized GPA in a 45-year-old female patients. The disease occurred with local damage to the upper respiratory tract, granulomatous inflammation of the pulmonary vessels to form multiple infiltrates with lung tissue destruction elements and necrotizing glomerulonephritis. Despite intensive immunosuppressive treatment, there was a rapid GPA progression with the further development of respiratory failure, which had been induced by stenotic laryngitis subglottica leading to tracheostoma. Damage to the organ of vision could lead to severe complications, including amaurosis. RMT was shown to be effective in treating generalized GPA with a poor prognosis. |
| format | Article |
| id | doaj-art-2e86a542daca49e5b777bb193fc71293 |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2014-12-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-2e86a542daca49e5b777bb193fc712932025-08-20T03:59:57ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2014-12-0184434710.14412/1996-7012-2014-4-43-471875Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case reportGulazyk Malikovna Koilubaeva0R. I. Rudenko1Z. A. Abdulkadyrova2V. T. Eralieva3National Center for Cardiology and TherapyNational Center for Cardiology and TherapyNational Center for Cardiology and TherapyNational Center for Cardiology and TherapySystemic vasculitides (SVs) are characterized by inflammation of the blood vessels wall; the spectrum of their clinical manifestations depends on the type, extent, and location of affected vessels and the activity of systemic inflammation. The etiology of most primary SVs is unknown. Antineutrophil cytoplasmic antibodies (ANCAs) are implicated in its pathogenesis. The presence of ANCAa in patients' serum and the correlation of their level with the severity of clinical manifestations served as a basis for identifying a subgroup of systemic necrotizing vasculitides associated with ANCA synthesis: granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and Churg – Strauss syndrome. GPA is characterized by systemic granulomatous necrotizing vasculitis involving the small vessels of the upper respiratory tract, lung, and kidney.The paper describes a case of difficult diagnosis and successful rituximab (RTM) treatment of generalized GPA in a 45-year-old female patients. The disease occurred with local damage to the upper respiratory tract, granulomatous inflammation of the pulmonary vessels to form multiple infiltrates with lung tissue destruction elements and necrotizing glomerulonephritis. Despite intensive immunosuppressive treatment, there was a rapid GPA progression with the further development of respiratory failure, which had been induced by stenotic laryngitis subglottica leading to tracheostoma. Damage to the organ of vision could lead to severe complications, including amaurosis. RMT was shown to be effective in treating generalized GPA with a poor prognosis.https://mrj.ima-press.net/mrj/article/view/574systemic vasculitidesgranulomatosis with polyangiitisdiagnosistreatment |
| spellingShingle | Gulazyk Malikovna Koilubaeva R. I. Rudenko Z. A. Abdulkadyrova V. T. Eralieva Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report Современная ревматология systemic vasculitides granulomatosis with polyangiitis diagnosis treatment |
| title | Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report |
| title_full | Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report |
| title_fullStr | Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report |
| title_full_unstemmed | Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report |
| title_short | Efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis: A case report |
| title_sort | efficiency of using rituximab in a patient with generalized granulomatosis with polyangiitis a case report |
| topic | systemic vasculitides granulomatosis with polyangiitis diagnosis treatment |
| url | https://mrj.ima-press.net/mrj/article/view/574 |
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