Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma
Abstract Background Invasive Cerebral Aspergillosis (ICA) is a rare fungal infection affecting the brain, primarily seen in individuals with compromised immune systems. Despite various treatment options, substantial cerebral granulomas caused by ICA still result in high mortality and recurrence rate...
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| Language: | English |
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BMC
2025-04-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10884-9 |
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| author | Zhiwei Zhou Xueqin Hu Jingwen Wang Nianhua Wang |
| author_facet | Zhiwei Zhou Xueqin Hu Jingwen Wang Nianhua Wang |
| author_sort | Zhiwei Zhou |
| collection | DOAJ |
| description | Abstract Background Invasive Cerebral Aspergillosis (ICA) is a rare fungal infection affecting the brain, primarily seen in individuals with compromised immune systems. Despite various treatment options, substantial cerebral granulomas caused by ICA still result in high mortality and recurrence rates. Case presentation We report a rare instance of ICA in a 30-year-old pregnant woman. The infection initiated in the nasal cavity and progressed to form a large intracranial granuloma, leading to brain herniation. Diagnosis was confirmed through histopathology, Polymerase Chain Reaction (PCR), and metagenomic next-generation sequencing (mNGS) following decompressive craniotomy and sinus window drainage surgery. Prompt administration of antifungal medication resulted in a favorable prognosis. Conclusion This case highlights the critical roles of mNGS and PCR in the early diagnosis of ICA, as well as the pivotal importance of surgical interventions and prompt initiation of antifungal therapy in enhancing patient outcomes. |
| format | Article |
| id | doaj-art-2e85e070021b4901b854eb47b253db59 |
| institution | DOAJ |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-2e85e070021b4901b854eb47b253db592025-08-20T03:10:09ZengBMCBMC Infectious Diseases1471-23342025-04-012511610.1186/s12879-025-10884-9Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granulomaZhiwei Zhou0Xueqin Hu1Jingwen Wang2Nianhua Wang3Department of Neurosurgery, Xiangya School of Medicine, The First People’s Hospital of Changde City, Central South UniversityDepartment of Neurosurgery, Xiangya School of Medicine, The First People’s Hospital of Changde City, Central South UniversityDepartment of Obstetrics and Gynecology, Xiangya School of Medicine, The First People’s Hospital of Changde City, Central South UniversityDepartment of Neurosurgery, Xiangya School of Medicine, The First People’s Hospital of Changde City, Central South UniversityAbstract Background Invasive Cerebral Aspergillosis (ICA) is a rare fungal infection affecting the brain, primarily seen in individuals with compromised immune systems. Despite various treatment options, substantial cerebral granulomas caused by ICA still result in high mortality and recurrence rates. Case presentation We report a rare instance of ICA in a 30-year-old pregnant woman. The infection initiated in the nasal cavity and progressed to form a large intracranial granuloma, leading to brain herniation. Diagnosis was confirmed through histopathology, Polymerase Chain Reaction (PCR), and metagenomic next-generation sequencing (mNGS) following decompressive craniotomy and sinus window drainage surgery. Prompt administration of antifungal medication resulted in a favorable prognosis. Conclusion This case highlights the critical roles of mNGS and PCR in the early diagnosis of ICA, as well as the pivotal importance of surgical interventions and prompt initiation of antifungal therapy in enhancing patient outcomes.https://doi.org/10.1186/s12879-025-10884-9PregnancyInvasive aspergillus flavus infectionIntracranialGiant granulomaCranial hypertensionMetagenomic next-generation sequencing |
| spellingShingle | Zhiwei Zhou Xueqin Hu Jingwen Wang Nianhua Wang Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma BMC Infectious Diseases Pregnancy Invasive aspergillus flavus infection Intracranial Giant granuloma Cranial hypertension Metagenomic next-generation sequencing |
| title | Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma |
| title_full | Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma |
| title_fullStr | Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma |
| title_full_unstemmed | Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma |
| title_short | Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma |
| title_sort | invasive cerebral aspergillosis in a pregnant woman a rare case of intracranial giant granuloma |
| topic | Pregnancy Invasive aspergillus flavus infection Intracranial Giant granuloma Cranial hypertension Metagenomic next-generation sequencing |
| url | https://doi.org/10.1186/s12879-025-10884-9 |
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