Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study
The objective of this paper is to investigate the effects of liraglutide in combination with short-term continuous subcutaneous insulin infusion (CSII) therapy on glycemic control and beta cell function in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Thirty-nine eligible newly diag...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6839735 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850106299963932672 |
|---|---|
| author | Weijian Ke Liehua Liu Juan Liu Ailing Chen Wanping Deng Pengyuan Zhang Xiaopei Cao Zhihong Liao Haipeng Xiao Jianbin Liu Yanbing Li |
| author_facet | Weijian Ke Liehua Liu Juan Liu Ailing Chen Wanping Deng Pengyuan Zhang Xiaopei Cao Zhihong Liao Haipeng Xiao Jianbin Liu Yanbing Li |
| author_sort | Weijian Ke |
| collection | DOAJ |
| description | The objective of this paper is to investigate the effects of liraglutide in combination with short-term continuous subcutaneous insulin infusion (CSII) therapy on glycemic control and beta cell function in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Thirty-nine eligible newly diagnosed T2DM patients were recruited and randomized to receive either of two therapies: short-term CSII alone (CSII alone group) or CSII in combination with liraglutide (CSII + Lira group) for 12 weeks. Blood glucose control, homeostasis model assessment (HOMA) indices, and acute insulin response (AIR) were compared between the two groups. The patients in CSII + Lira group achieved euglycemia with equivalent insulin dosage in shorter time (1 (0) versus 2 (3) days, P=0.039). HbA1c at the end of study was comparable between two groups (6.3±0.7% versus 6.0±0.5%, for CSII alone group and CSII + Lira group, resp., P=0.325). The increment of AIR was higher in CSII + Lira group (177.58 (351.57) μU·min/mL versus 58.15 (51.30) μU·min/mL, P<0.001). However, after stopping liraglutide, its effect on beta cell function disappeared completely. Liraglutide combined with short-term CSII was effective in further improving beta cell function, but the beneficial effects did not sustain after suspension of the therapy. |
| format | Article |
| id | doaj-art-2e837212cb694a998de18f7df766a91e |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2e837212cb694a998de18f7df766a91e2025-08-20T02:38:51ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/68397356839735Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot StudyWeijian Ke0Liehua Liu1Juan Liu2Ailing Chen3Wanping Deng4Pengyuan Zhang5Xiaopei Cao6Zhihong Liao7Haipeng Xiao8Jianbin Liu9Yanbing Li10Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, ChinaThe objective of this paper is to investigate the effects of liraglutide in combination with short-term continuous subcutaneous insulin infusion (CSII) therapy on glycemic control and beta cell function in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Thirty-nine eligible newly diagnosed T2DM patients were recruited and randomized to receive either of two therapies: short-term CSII alone (CSII alone group) or CSII in combination with liraglutide (CSII + Lira group) for 12 weeks. Blood glucose control, homeostasis model assessment (HOMA) indices, and acute insulin response (AIR) were compared between the two groups. The patients in CSII + Lira group achieved euglycemia with equivalent insulin dosage in shorter time (1 (0) versus 2 (3) days, P=0.039). HbA1c at the end of study was comparable between two groups (6.3±0.7% versus 6.0±0.5%, for CSII alone group and CSII + Lira group, resp., P=0.325). The increment of AIR was higher in CSII + Lira group (177.58 (351.57) μU·min/mL versus 58.15 (51.30) μU·min/mL, P<0.001). However, after stopping liraglutide, its effect on beta cell function disappeared completely. Liraglutide combined with short-term CSII was effective in further improving beta cell function, but the beneficial effects did not sustain after suspension of the therapy.http://dx.doi.org/10.1155/2016/6839735 |
| spellingShingle | Weijian Ke Liehua Liu Juan Liu Ailing Chen Wanping Deng Pengyuan Zhang Xiaopei Cao Zhihong Liao Haipeng Xiao Jianbin Liu Yanbing Li Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study Journal of Diabetes Research |
| title | Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study |
| title_full | Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study |
| title_fullStr | Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study |
| title_full_unstemmed | Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study |
| title_short | Effects of Liraglutide Combined with Short-Term Continuous Subcutaneous Insulin Infusion on Glycemic Control and Beta Cell Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Pilot Study |
| title_sort | effects of liraglutide combined with short term continuous subcutaneous insulin infusion on glycemic control and beta cell function in patients with newly diagnosed type 2 diabetes mellitus a pilot study |
| url | http://dx.doi.org/10.1155/2016/6839735 |
| work_keys_str_mv | AT weijianke effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT liehualiu effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT juanliu effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT ailingchen effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT wanpingdeng effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT pengyuanzhang effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT xiaopeicao effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT zhihongliao effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT haipengxiao effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT jianbinliu effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy AT yanbingli effectsofliraglutidecombinedwithshorttermcontinuoussubcutaneousinsulininfusiononglycemiccontrolandbetacellfunctioninpatientswithnewlydiagnosedtype2diabetesmellitusapilotstudy |