A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada
Background. Routine vaccination against Streptococcus pneumoniae is recommended in Canada for infants, the elderly, and individuals with chronic comorbidity. National incidence and burden of all-cause and pneumococcal pneumonia in Canada (excluding Quebec) were assessed. Methods. Incidence, length o...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/3605834 |
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| author | Shelly A. McNeil Nawab Qizilbash Jian Ye Sharon Gray Giovanni Zanotti Samantha Munson Nathalie Dartois Craig Laferriere |
| author_facet | Shelly A. McNeil Nawab Qizilbash Jian Ye Sharon Gray Giovanni Zanotti Samantha Munson Nathalie Dartois Craig Laferriere |
| author_sort | Shelly A. McNeil |
| collection | DOAJ |
| description | Background. Routine vaccination against Streptococcus pneumoniae is recommended in Canada for infants, the elderly, and individuals with chronic comorbidity. National incidence and burden of all-cause and pneumococcal pneumonia in Canada (excluding Quebec) were assessed. Methods. Incidence, length of stay, and case-fatality rates of hospitalized all-cause and pneumococcal pneumonia were determined for 2004–2010 using ICD-10 discharge data from the Canadian Institutes for Health Information Discharge Abstract Database. Population-at-risk data were obtained from the Statistics Canada census. Temporal changes in pneumococcal and all-cause pneumonia rates in adults ≥65 years were analyzed by logistic regression. Results. Hospitalization for all-cause pneumonia was highest in children <5 years and in adults >70 years and declined significantly from 1766/100,000 to 1537/100,000 per year in individuals aged ≥65 years (P<0.001). Overall hospitalization for pneumococcal pneumonia also declined from 6.40/100,000 to 5.08/100,000 per year. Case-fatality rates were stable (11.6% to 12.3%). Elderly individuals had longer length of stay and higher case-fatality rates than younger groups. Conclusions. All-cause and pneumococcal pneumonia hospitalization rates declined between 2004 and 2010 in Canada (excluding Quebec). Direct and indirect effects from pediatric pneumococcal immunization may partly explain some of this decline. Nevertheless, the burden of disease from pneumonia remains high. |
| format | Article |
| id | doaj-art-2e811b93ed31434e826e0c8f829bc6cb |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-2e811b93ed31434e826e0c8f829bc6cb2025-08-20T03:55:07ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/36058343605834A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in CanadaShelly A. McNeil0Nawab Qizilbash1Jian Ye2Sharon Gray3Giovanni Zanotti4Samantha Munson5Nathalie Dartois6Craig Laferriere7Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, B3K 6R8, CanadaOXON Epidemiology Ltd., London NW1 2FD, UKPfizer Inc., Collegeville, PA 19426, USAPfizer Inc., Collegeville, PA 19426, USAPfizer Canada, Kirkland, QC, H9J 2M5, CanadaPfizer Inc., Collegeville, PA 19426, USAPfizer, 75668 Paris Cedex 14, FrancePfizer Canada, Kirkland, QC, H9J 2M5, CanadaBackground. Routine vaccination against Streptococcus pneumoniae is recommended in Canada for infants, the elderly, and individuals with chronic comorbidity. National incidence and burden of all-cause and pneumococcal pneumonia in Canada (excluding Quebec) were assessed. Methods. Incidence, length of stay, and case-fatality rates of hospitalized all-cause and pneumococcal pneumonia were determined for 2004–2010 using ICD-10 discharge data from the Canadian Institutes for Health Information Discharge Abstract Database. Population-at-risk data were obtained from the Statistics Canada census. Temporal changes in pneumococcal and all-cause pneumonia rates in adults ≥65 years were analyzed by logistic regression. Results. Hospitalization for all-cause pneumonia was highest in children <5 years and in adults >70 years and declined significantly from 1766/100,000 to 1537/100,000 per year in individuals aged ≥65 years (P<0.001). Overall hospitalization for pneumococcal pneumonia also declined from 6.40/100,000 to 5.08/100,000 per year. Case-fatality rates were stable (11.6% to 12.3%). Elderly individuals had longer length of stay and higher case-fatality rates than younger groups. Conclusions. All-cause and pneumococcal pneumonia hospitalization rates declined between 2004 and 2010 in Canada (excluding Quebec). Direct and indirect effects from pediatric pneumococcal immunization may partly explain some of this decline. Nevertheless, the burden of disease from pneumonia remains high.http://dx.doi.org/10.1155/2016/3605834 |
| spellingShingle | Shelly A. McNeil Nawab Qizilbash Jian Ye Sharon Gray Giovanni Zanotti Samantha Munson Nathalie Dartois Craig Laferriere A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada Canadian Respiratory Journal |
| title | A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada |
| title_full | A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada |
| title_fullStr | A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada |
| title_full_unstemmed | A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada |
| title_short | A Retrospective Study of the Clinical Burden of Hospitalized All-Cause and Pneumococcal Pneumonia in Canada |
| title_sort | retrospective study of the clinical burden of hospitalized all cause and pneumococcal pneumonia in canada |
| url | http://dx.doi.org/10.1155/2016/3605834 |
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