LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells
Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tu...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-10-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317721440 |
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| _version_ | 1849428587723096064 |
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| author | Wanjun Yu Weidong Peng Hao Jiang Hanyun Sha Jipeng Li |
| author_facet | Wanjun Yu Weidong Peng Hao Jiang Hanyun Sha Jipeng Li |
| author_sort | Wanjun Yu |
| collection | DOAJ |
| description | Long non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes non–small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in non–small cell lung cancer tumorigenesis. |
| format | Article |
| id | doaj-art-2e792cc0d017488d92e360f654f33f1a |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-2e792cc0d017488d92e360f654f33f1a2025-08-20T03:28:40ZengSAGE PublishingTumor Biology1423-03802017-10-013910.1177/1010428317721440LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cellsWanjun Yu0Weidong Peng1Hao Jiang2Hanyun Sha3Jipeng Li4Department of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Respiratory and Critical Care Medicine, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Nephrology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaDepartment of Central Laboratory, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, ChinaLong non-coding RNAs have been implicated in human cancer but their mechanisms of action are mainly undocumented. In this study, we found that HOXA11-AS expression was upregulated in non–small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes non–small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in non–small cell lung cancer tumorigenesis.https://doi.org/10.1177/1010428317721440 |
| spellingShingle | Wanjun Yu Weidong Peng Hao Jiang Hanyun Sha Jipeng Li LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells Tumor Biology |
| title | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells |
| title_full | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells |
| title_fullStr | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells |
| title_full_unstemmed | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells |
| title_short | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non–small cell lung cancer cells |
| title_sort | lncrna hoxa11 as promotes proliferation and invasion by targeting mir 124 in human non small cell lung cancer cells |
| url | https://doi.org/10.1177/1010428317721440 |
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