Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study
ObjectivesThis study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in lumbar spine BMD and the potential implications for osteoporosi...
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| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2025.1511294/full |
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| author | Aiguo Liu Aiguo Liu Ting Ying Shuang Deng Chenxu Wang Chenxu Wang Ziwen Zhao Sitong Zhang Han Xiao Chengqing Yi Dejian Li |
| author_facet | Aiguo Liu Aiguo Liu Ting Ying Shuang Deng Chenxu Wang Chenxu Wang Ziwen Zhao Sitong Zhang Han Xiao Chengqing Yi Dejian Li |
| author_sort | Aiguo Liu |
| collection | DOAJ |
| description | ObjectivesThis study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in lumbar spine BMD and the potential implications for osteoporosis risk.MethodsA cross-sectional analysis was conducted involving 3,057 participants (1,555 males and 1,502 females). Participants were stratified into quartiles based on baseline ACAG levels. Demographic and clinical characteristics were analyzed, including age, sex, education level, body mass index (BMI), and prevalence of diabetes and hypertension. The association between ACAG and lumbar spine BMD was evaluated using multiple regression models, and a generalized additive model was employed to identify potential nonlinear relationships.ResultsThe analysis revealed a significant negative correlation between ACAG and lumbar spine BMD (P < 0.001). For each 1-unit increase in ACAG, BMD decreased with β coefficients of −0.004 to −0.005 across various models. Quartile analysis indicated that participants in the highest ACAG quartile (≥19.55) experienced the most substantial reductions in BMD (β coefficients ranging from −0.034 to −0.036, P < 0.001). Furthermore, a U-shaped relationship was identified, with a turning point at an ACAG value of 22.15, indicating that lower ACAG levels were associated with decreased BMD, while higher levels showed a positive effect. Subgroup analyses by sex demonstrated consistent findings, with significant associations in both males and females.ConclusionThe findings underscore a significant association between elevated ACAG levels and reduced lumbar spine BMD, suggesting that ACAG may serve as a valuable biomarker for assessing osteoporosis risk. The identified nonlinear relationship further emphasizes the complexity of metabolic influences on bone health. These results warrant further investigation into the mechanisms underlying ACAG’s impact on bone density and its potential role in osteoporosis prevention strategies. |
| format | Article |
| id | doaj-art-2e7583ec7d7e4809addfb86b93246e69 |
| institution | Kabale University |
| issn | 2673-6217 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj-art-2e7583ec7d7e4809addfb86b93246e692025-02-11T06:59:57ZengFrontiers Media S.A.Frontiers in Aging2673-62172025-02-01610.3389/fragi.2025.15112941511294Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional studyAiguo Liu0Aiguo Liu1Ting Ying2Shuang Deng3Chenxu Wang4Chenxu Wang5Ziwen Zhao6Sitong Zhang7Han Xiao8Chengqing Yi9Dejian Li10Department of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaObjectivesThis study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in lumbar spine BMD and the potential implications for osteoporosis risk.MethodsA cross-sectional analysis was conducted involving 3,057 participants (1,555 males and 1,502 females). Participants were stratified into quartiles based on baseline ACAG levels. Demographic and clinical characteristics were analyzed, including age, sex, education level, body mass index (BMI), and prevalence of diabetes and hypertension. The association between ACAG and lumbar spine BMD was evaluated using multiple regression models, and a generalized additive model was employed to identify potential nonlinear relationships.ResultsThe analysis revealed a significant negative correlation between ACAG and lumbar spine BMD (P < 0.001). For each 1-unit increase in ACAG, BMD decreased with β coefficients of −0.004 to −0.005 across various models. Quartile analysis indicated that participants in the highest ACAG quartile (≥19.55) experienced the most substantial reductions in BMD (β coefficients ranging from −0.034 to −0.036, P < 0.001). Furthermore, a U-shaped relationship was identified, with a turning point at an ACAG value of 22.15, indicating that lower ACAG levels were associated with decreased BMD, while higher levels showed a positive effect. Subgroup analyses by sex demonstrated consistent findings, with significant associations in both males and females.ConclusionThe findings underscore a significant association between elevated ACAG levels and reduced lumbar spine BMD, suggesting that ACAG may serve as a valuable biomarker for assessing osteoporosis risk. The identified nonlinear relationship further emphasizes the complexity of metabolic influences on bone health. These results warrant further investigation into the mechanisms underlying ACAG’s impact on bone density and its potential role in osteoporosis prevention strategies.https://www.frontiersin.org/articles/10.3389/fragi.2025.1511294/fullACAGBMDosteoporosisNHANEScross-sectional analysis |
| spellingShingle | Aiguo Liu Aiguo Liu Ting Ying Shuang Deng Chenxu Wang Chenxu Wang Ziwen Zhao Sitong Zhang Han Xiao Chengqing Yi Dejian Li Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study Frontiers in Aging ACAG BMD osteoporosis NHANES cross-sectional analysis |
| title | Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study |
| title_full | Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study |
| title_fullStr | Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study |
| title_full_unstemmed | Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study |
| title_short | Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study |
| title_sort | relationship between albumin corrected anion gap and lumbar spine bone mineral density a cross sectional study |
| topic | ACAG BMD osteoporosis NHANES cross-sectional analysis |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2025.1511294/full |
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