Interplay between physical activity, inflammation, and cognitive performance in women with type 2 diabetes: an observational study focused on IL-6 pathway mediators

Interplay between physical activity, inflammation, and cognitive performance in women with type 2 diabetes: an observational study focused on IL-6 pathway mediators

Abstract Introduction Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment, with dysregulation of the interleukin-6 (IL-6) signaling pathway—particularly its soluble receptors—implicated in both T2DM pathogenesis and cognitive dysfunction. The potential role of sIL-6R (soluble int...

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Bibliographic Details
Main Authors: Zakieh Heidari, Mahdieh Molanouri Shamsi, Amin Kadkhodaei, Mehrdad Behmanesh, Shahnaz Shahrbanian, Sara Soudi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Type 2 diabetes mellitus
Cognitive function
Physical activity
Metabolic health
IL-6
sIL-6R
Online Access:https://doi.org/10.1186/s13098-025-01908-0
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