Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup
Introduction. 18F-FDG-PET-CT plays an important role in the management of lymphoma postchemotherapy followup. Some centres perform prechemotherapy baseline CT and postchemotherapy PETCT. With a concern of radiation burden, especially in young patients, this study aimed to assess if PETCT radiation d...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/208135 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849306326235086848 |
|---|---|
| author | L. I. Sonoda B. Sanghera W. L. Wong |
| author_facet | L. I. Sonoda B. Sanghera W. L. Wong |
| author_sort | L. I. Sonoda |
| collection | DOAJ |
| description | Introduction. 18F-FDG-PET-CT plays an important role in the management of lymphoma postchemotherapy followup. Some centres perform prechemotherapy baseline CT and postchemotherapy PETCT. With a concern of radiation burden, especially in young patients, this study aimed to assess if PETCT radiation dose could be reduced. Methods. Retrospective analysis of 100 lymphoma patients was performed to record sites of disease on prechemotherapy CT and postchemotherapy PETCT. The potential reduction in radiation and time achieved with PETCT limited to sites of known disease identified on prechemotherapy CT was calculated. Results. No FDG-uptake was seen in 72 cases. FDG uptake at known disease sites was seen in 24. Of the remaining 4, one had clinically significant pathology, a rectal adenocarcinoma. PETCT did not reveal any unexpected sites of lymphoma. Limiting PETCT to sites of known disease would have saved a mean radiation dose of 4 mSv (27.3%), with a mean time of 16 minutes. Conclusion. Our study suggests that young patients may benefit from reduced radiation by limiting PETCT to sites of known disease with low risk of missing significant pathology. However, in older patients, with increased incidence of asymptomatic synchronous malignancies, whole-body PETCT is advisable unless prechemotherapy PETCT has been performed. |
| format | Article |
| id | doaj-art-2e703628edec4ee48df3cd04d20b7d64 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-2e703628edec4ee48df3cd04d20b7d642025-08-20T03:55:07ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/208135208135Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy FollowupL. I. Sonoda0B. Sanghera1W. L. Wong2Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UKPaul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UKPaul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, UKIntroduction. 18F-FDG-PET-CT plays an important role in the management of lymphoma postchemotherapy followup. Some centres perform prechemotherapy baseline CT and postchemotherapy PETCT. With a concern of radiation burden, especially in young patients, this study aimed to assess if PETCT radiation dose could be reduced. Methods. Retrospective analysis of 100 lymphoma patients was performed to record sites of disease on prechemotherapy CT and postchemotherapy PETCT. The potential reduction in radiation and time achieved with PETCT limited to sites of known disease identified on prechemotherapy CT was calculated. Results. No FDG-uptake was seen in 72 cases. FDG uptake at known disease sites was seen in 24. Of the remaining 4, one had clinically significant pathology, a rectal adenocarcinoma. PETCT did not reveal any unexpected sites of lymphoma. Limiting PETCT to sites of known disease would have saved a mean radiation dose of 4 mSv (27.3%), with a mean time of 16 minutes. Conclusion. Our study suggests that young patients may benefit from reduced radiation by limiting PETCT to sites of known disease with low risk of missing significant pathology. However, in older patients, with increased incidence of asymptomatic synchronous malignancies, whole-body PETCT is advisable unless prechemotherapy PETCT has been performed.http://dx.doi.org/10.1100/2012/208135 |
| spellingShingle | L. I. Sonoda B. Sanghera W. L. Wong Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup The Scientific World Journal |
| title | Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup |
| title_full | Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup |
| title_fullStr | Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup |
| title_full_unstemmed | Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup |
| title_short | Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup |
| title_sort | investigation of dose minimisation protocol for 18f fdg pet ct in the management of lymphoma postchemotherapy followup |
| url | http://dx.doi.org/10.1100/2012/208135 |
| work_keys_str_mv | AT lisonoda investigationofdoseminimisationprotocolfor18ffdgpetctinthemanagementoflymphomapostchemotherapyfollowup AT bsanghera investigationofdoseminimisationprotocolfor18ffdgpetctinthemanagementoflymphomapostchemotherapyfollowup AT wlwong investigationofdoseminimisationprotocolfor18ffdgpetctinthemanagementoflymphomapostchemotherapyfollowup |