Contributing factors to the oxidation-induced mutational landscape in human cells

Contributing factors to the oxidation-induced mutational landscape in human cells

Abstract 8-oxoguanine (8-oxoG) is a common oxidative DNA lesion that causes G > T substitutions. Determinants of local and regional differences in 8-oxoG-induced mutability across genomes are currently unknown. Here, we show DNA oxidation induces G > T substitutions and insertion/deletion (IND...

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Bibliographic Details
Main Authors: Cameron Cordero, Kavi P. M. Mehta, Tyler M. Weaver, Justin A. Ling, Bret D. Freudenthal, David Cortez, Steven A. Roberts
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55497-z
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