The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus
The role of renin-angiotensin system (RAS) in general and angiotensin-converting enzyme 2 (ACE2) in particular in the pathogenesis and course of viral infection caused by SARS-CoV-2 (COVID-19) is of particular interest. This is due not only to the fact that ACE2 is a receptor for the virus...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2020-08-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12501 |
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| author | O. K. Vikulova Zamira Zuraeva L. V. Nikankina M. V. Shestakova |
| author_facet | O. K. Vikulova Zamira Zuraeva L. V. Nikankina M. V. Shestakova |
| author_sort | O. K. Vikulova |
| collection | DOAJ |
| description | The role of renin-angiotensin system (RAS) in general and angiotensin-converting enzyme 2 (ACE2) in particular in the pathogenesis and course of viral infection caused by SARS-CoV-2 (COVID-19) is of particular interest. This is due not only to the fact that ACE2 is a receptor for the virus the target cells. RAS hyperactivation in patients with arterial hypertension, cardiovascular disease and diabetes mellitus, is considered one of the most important factors for a more severe infection in persons with concomitant pathology. In addition, the effects of PAS blockage with angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs) remains one of the most discussed topics in the literature on COVID-19. This review presents the data on the interaction between the virus and the main components of RAS and the factors influencing their expression level, the impact of ACE ­inhibitors and ARBs therapy on the disease outcome, and presents the perspectives of the treatment with recombinant ACE 2. |
| format | Article |
| id | doaj-art-2e6e034a89ad47b4a20496474adbda7d |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-2e6e034a89ad47b4a20496474adbda7d2025-08-20T03:47:53ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782020-08-0123324224910.14341/DM1250110707The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitusO. K. Vikulova0Zamira Zuraeva1L. V. Nikankina2M. V. Shestakova3Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreThe role of renin-angiotensin system (RAS) in general and angiotensin-converting enzyme 2 (ACE2) in particular in the pathogenesis and course of viral infection caused by SARS-CoV-2 (COVID-19) is of particular interest. This is due not only to the fact that ACE2 is a receptor for the virus the target cells. RAS hyperactivation in patients with arterial hypertension, cardiovascular disease and diabetes mellitus, is considered one of the most important factors for a more severe infection in persons with concomitant pathology. In addition, the effects of PAS blockage with angiotensin converting enzyme inhibitors (ACE inhibitors) and angiotensin II receptor blockers (ARBs) remains one of the most discussed topics in the literature on COVID-19. This review presents the data on the interaction between the virus and the main components of RAS and the factors influencing their expression level, the impact of ACE ­inhibitors and ARBs therapy on the disease outcome, and presents the perspectives of the treatment with recombinant ACE 2.https://www.dia-endojournals.ru/jour/article/view/12501sars-cov-2covid-19diabetes mellitusrenin-angiotensin systemangiotensin converting enzyme 2angiotensin 1-7¬angiotensin iiangiotensin converting enzyme inhibitorsangiotensin ii receptor blockers |
| spellingShingle | O. K. Vikulova Zamira Zuraeva L. V. Nikankina M. V. Shestakova The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus Сахарный диабет sars-cov-2 covid-19 diabetes mellitus renin-angiotensin system angiotensin converting enzyme 2 angiotensin 1-7 ¬angiotensin ii angiotensin converting enzyme inhibitors angiotensin ii receptor blockers |
| title | The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus |
| title_full | The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus |
| title_fullStr | The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus |
| title_full_unstemmed | The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus |
| title_short | The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus |
| title_sort | role of renin angiotensin system and angiotensin converting enzyme 2 ace2 in the development and course of viral infection covid 19 in patients with diabetes mellitus |
| topic | sars-cov-2 covid-19 diabetes mellitus renin-angiotensin system angiotensin converting enzyme 2 angiotensin 1-7 ¬angiotensin ii angiotensin converting enzyme inhibitors angiotensin ii receptor blockers |
| url | https://www.dia-endojournals.ru/jour/article/view/12501 |
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