An immunotherapy guide constructed by cGAS-STING signature for breast cancer and the biofunction validation of the pivotal gene HOXC13 via in vitro experiments

An immunotherapy guide constructed by cGAS-STING signature for breast cancer and the biofunction validation of the pivotal gene HOXC13 via in vitro experiments

ObjectiveAs the most common cancer in women, immunotherapy has become a pivotal element in the treatment of breast cancer, particularly for cases resistant to traditional therapies. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is recognized as the primary DNA-sen...

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Bibliographic Details
Main Authors: Zhenling Dai, Ziqun Gu, Rongrong Shen, Jingshuai Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
HOXC13
immunotherapy
cGAS-STING
subgrouping
breast cancer
Support Vector Machine (SVM)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586877/full
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