Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons
Kalirin-7 (Kal7), a major isoform of Kalirin in the adult rodent hippocampus, is exclusively localized to the postsynaptic side of mature excitatory synapses in hippocampal neurons. Kal7 interacts with multiple PDZ domain—containing proteins through its unique PDZ binding motif. Overexpression of Ka...
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.148 |
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| author | Xin-Ming Ma |
| author_facet | Xin-Ming Ma |
| author_sort | Xin-Ming Ma |
| collection | DOAJ |
| description | Kalirin-7 (Kal7), a major isoform of Kalirin in the adult rodent hippocampus, is exclusively localized to the postsynaptic side of mature excitatory synapses in hippocampal neurons. Kal7 interacts with multiple PDZ domain—containing proteins through its unique PDZ binding motif. Overexpression of Kal7 increases spine density and spine size, whereas reduction of endogenous Kal7 expression by small hairpin RNA (shRNA) causes a decrease in synapse number and spine density in cultured hippocampal neurons. Hippocampal CA1 pyramidal neurons of Kal7 knockout (Kal7KO) mice show decreased spine density, spine length, synapse number, and postsynaptic density (PSD) size in their apical dendrites; are deficient in long-term potentiation (LTP); and exhibit decreased frequency of spontaneous excitatory postsynaptic current (sEPSC). Kal7 plays a key role in estrogen-mediated spine/synapse formation in hippocampal neurons. Kal7 is also an essential determinant of dendritic spine formation following chronic cocaine treatment. Kal7 plays a key role in excitatory synapse formation and function. |
| format | Article |
| id | doaj-art-2e6a3826ed6f4a0bb597cdea5dd96ca4 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-2e6a3826ed6f4a0bb597cdea5dd96ca42025-08-20T03:18:28ZengWileyThe Scientific World Journal1537-744X2010-01-01101655166610.1100/tsw.2010.148Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal NeuronsXin-Ming Ma0Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USAKalirin-7 (Kal7), a major isoform of Kalirin in the adult rodent hippocampus, is exclusively localized to the postsynaptic side of mature excitatory synapses in hippocampal neurons. Kal7 interacts with multiple PDZ domain—containing proteins through its unique PDZ binding motif. Overexpression of Kal7 increases spine density and spine size, whereas reduction of endogenous Kal7 expression by small hairpin RNA (shRNA) causes a decrease in synapse number and spine density in cultured hippocampal neurons. Hippocampal CA1 pyramidal neurons of Kal7 knockout (Kal7KO) mice show decreased spine density, spine length, synapse number, and postsynaptic density (PSD) size in their apical dendrites; are deficient in long-term potentiation (LTP); and exhibit decreased frequency of spontaneous excitatory postsynaptic current (sEPSC). Kal7 plays a key role in estrogen-mediated spine/synapse formation in hippocampal neurons. Kal7 is also an essential determinant of dendritic spine formation following chronic cocaine treatment. Kal7 plays a key role in excitatory synapse formation and function.http://dx.doi.org/10.1100/tsw.2010.148 |
| spellingShingle | Xin-Ming Ma Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons The Scientific World Journal |
| title | Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons |
| title_full | Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons |
| title_fullStr | Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons |
| title_full_unstemmed | Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons |
| title_short | Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons |
| title_sort | kalirin 7 is a key player in the formation of excitatory synapses in hippocampal neurons |
| url | http://dx.doi.org/10.1100/tsw.2010.148 |
| work_keys_str_mv | AT xinmingma kalirin7isakeyplayerintheformationofexcitatorysynapsesinhippocampalneurons |