Family history of disease and risk of glioma occurrence: Results of the case-control study
Background/Aim. Malignant gliomas represent a heterogenaus group of tumors. They occur in all age groups, predominatly in males in older age. The purpose of this case-control study was to examine the association between risk for developing glioma and family history of diseases. Methods. The case-con...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2020-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84502000001A.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850237721436487680 |
|---|---|
| author | Azanjac-Arsić Ana Tončev Gordana Miletić-Drakulić Svetlana Vesić Katarina Aleksić Dejan Marić Gorica Pekmezović Tatjana |
| author_facet | Azanjac-Arsić Ana Tončev Gordana Miletić-Drakulić Svetlana Vesić Katarina Aleksić Dejan Marić Gorica Pekmezović Tatjana |
| author_sort | Azanjac-Arsić Ana |
| collection | DOAJ |
| description | Background/Aim. Malignant gliomas represent a heterogenaus group of tumors. They occur in all age groups, predominatly in males in older age. The purpose of this case-control study was to examine the association between risk for developing glioma and family history of diseases. Methods. The case-control study included 100 pathologically confirmed cases of glioma at the Clinical Centre Kragujevac, Serbia, between 2015 and 2016, and 200 ageand sex-matched controls without glioma and other malignant diseases in personal and family history at the same institution. After signing the informed consent all the patients filled out an epidemiological questionnaire. Multivariate logistic regression analysies was used in statistical data processing. Results. Malignant diseases in family history were more common in the study group than in the control group [odds ratio (OR) = 1.821, 95% confidence interval (CI) 1.004–3.305; p = 0.049]. The most common malignant tumor in the study group were cancer of the uterus (7%) and colon cancer (6%), while in the control group the most common cancer were lung cancer (6%) and cancer of the uterus (7%). Diabetes mellitus in family history was more common among control individuals than among glioma patients (OR = 0.520, 95% CI = 0.271– 0.995; p = 0.048). Also, our results showed that cardiovascular diseases in family history were more common in the control group than among patients of the study group (OR = 0.557, 95% CI = 0.325–0.953; p = 0.033). Conclusion. In this case-control study, we observed a statistically significant relation between family history of malignant diseases and glioma. Also, we found statistically significant inverse relation between family history of cardiovascular diseases and diabetes and glioma. |
| format | Article |
| id | doaj-art-2e68daecaf6548b590324ca3ca1211b3 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-2e68daecaf6548b590324ca3ca1211b32025-08-20T02:01:40ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202020-01-0177441341710.2298/VSP191127001A0042-84502000001AFamily history of disease and risk of glioma occurrence: Results of the case-control studyAzanjac-Arsić Ana0Tončev Gordana1Miletić-Drakulić Svetlana2Vesić Katarina3Aleksić Dejan4Marić Gorica5Pekmezović Tatjana6University of Kragujevac, Faculty of Medical Sciences, Department of Neurology, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Neurology, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Neurology, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Neurology, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Neurology, Kragujevac, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Epidemiology, Belgrade, Serbia University of Kragujevac, Faculty of Medical Sciences, Department of Neurology, Kragujevac, SerbiaBackground/Aim. Malignant gliomas represent a heterogenaus group of tumors. They occur in all age groups, predominatly in males in older age. The purpose of this case-control study was to examine the association between risk for developing glioma and family history of diseases. Methods. The case-control study included 100 pathologically confirmed cases of glioma at the Clinical Centre Kragujevac, Serbia, between 2015 and 2016, and 200 ageand sex-matched controls without glioma and other malignant diseases in personal and family history at the same institution. After signing the informed consent all the patients filled out an epidemiological questionnaire. Multivariate logistic regression analysies was used in statistical data processing. Results. Malignant diseases in family history were more common in the study group than in the control group [odds ratio (OR) = 1.821, 95% confidence interval (CI) 1.004–3.305; p = 0.049]. The most common malignant tumor in the study group were cancer of the uterus (7%) and colon cancer (6%), while in the control group the most common cancer were lung cancer (6%) and cancer of the uterus (7%). Diabetes mellitus in family history was more common among control individuals than among glioma patients (OR = 0.520, 95% CI = 0.271– 0.995; p = 0.048). Also, our results showed that cardiovascular diseases in family history were more common in the control group than among patients of the study group (OR = 0.557, 95% CI = 0.325–0.953; p = 0.033). Conclusion. In this case-control study, we observed a statistically significant relation between family history of malignant diseases and glioma. Also, we found statistically significant inverse relation between family history of cardiovascular diseases and diabetes and glioma.http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84502000001A.pdfglioma, family history of diseasemedical history takingepidemiologyneoplasms |
| spellingShingle | Azanjac-Arsić Ana Tončev Gordana Miletić-Drakulić Svetlana Vesić Katarina Aleksić Dejan Marić Gorica Pekmezović Tatjana Family history of disease and risk of glioma occurrence: Results of the case-control study Vojnosanitetski Pregled glioma, family history of disease medical history taking epidemiology neoplasms |
| title | Family history of disease and risk of glioma occurrence: Results of the case-control study |
| title_full | Family history of disease and risk of glioma occurrence: Results of the case-control study |
| title_fullStr | Family history of disease and risk of glioma occurrence: Results of the case-control study |
| title_full_unstemmed | Family history of disease and risk of glioma occurrence: Results of the case-control study |
| title_short | Family history of disease and risk of glioma occurrence: Results of the case-control study |
| title_sort | family history of disease and risk of glioma occurrence results of the case control study |
| topic | glioma, family history of disease medical history taking epidemiology neoplasms |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84502000001A.pdf |
| work_keys_str_mv | AT azanjacarsicana familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy AT toncevgordana familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy AT mileticdrakulicsvetlana familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy AT vesickatarina familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy AT aleksicdejan familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy AT maricgorica familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy AT pekmezovictatjana familyhistoryofdiseaseandriskofgliomaoccurrenceresultsofthecasecontrolstudy |