Markers of Anemia in Children with Type 1 Diabetes
Aim. The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± ...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5184354 |
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| author | Ewa Rusak Anna Rotarska-Mizera Piotr Adamczyk Bogdan Mazur Joanna Polanska Agata Chobot |
| author_facet | Ewa Rusak Anna Rotarska-Mizera Piotr Adamczyk Bogdan Mazur Joanna Polanska Agata Chobot |
| author_sort | Ewa Rusak |
| collection | DOAJ |
| description | Aim. The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). Sex- and age-matched controls (43 children). In all children, anthropometric measurements, the blood count, iron turnover parameters, and vitamin B12 concentration were taken. Results. T1DM children had significantly higher red cell distribution width (RDW) (13.6 versus 12.6%; p<0.001), hepcidin (0.25 versus 0.12 ng/ml; p<0.001), and vitamin B12 concentrations (459 versus 397 pg/ml; p<0.01) and lower TIBC (59.09 versus 68.15 μmol/l; p<0.001) than in the control group. Logistic regression revealed that RDW, TIBC (both p<0.001), and hepcidin (p<0.05) significantly differentiated both groups. In T1DM children, BMI SDS negatively correlated with vitamin B12 (p<0.01) concentration and mean corpuscular hemoglobin concentration (p<0.05) and positively with TIBC (p<0.01) and HbA1c (p<0.001). Conclusions. Patients and controls differed especially in terms of RDW and TIBC. In studied T1DM children, BMI SDS was associated to iron metabolism parameters and vitamin B12 concentration. |
| format | Article |
| id | doaj-art-2e663dad04184364b51d78cb3dbbd634 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2e663dad04184364b51d78cb3dbbd6342025-02-03T05:45:52ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/51843545184354Markers of Anemia in Children with Type 1 DiabetesEwa Rusak0Anna Rotarska-Mizera1Piotr Adamczyk2Bogdan Mazur3Joanna Polanska4Agata Chobot5Department of Pediatrics and Children’s Diabetology, Medical University of Silesia, 40-752 Katowice, PolandData Mining Division, Faculty of Automatic Control, Electronics, and Computer Science, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 40-752 Katowice, PolandData Mining Division, Faculty of Automatic Control, Electronics, and Computer Science, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Pediatric Gastroenterology and Hepatology, Clinical Hospital No. 1, 41-800 Zabrze, PolandAim. The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). Sex- and age-matched controls (43 children). In all children, anthropometric measurements, the blood count, iron turnover parameters, and vitamin B12 concentration were taken. Results. T1DM children had significantly higher red cell distribution width (RDW) (13.6 versus 12.6%; p<0.001), hepcidin (0.25 versus 0.12 ng/ml; p<0.001), and vitamin B12 concentrations (459 versus 397 pg/ml; p<0.01) and lower TIBC (59.09 versus 68.15 μmol/l; p<0.001) than in the control group. Logistic regression revealed that RDW, TIBC (both p<0.001), and hepcidin (p<0.05) significantly differentiated both groups. In T1DM children, BMI SDS negatively correlated with vitamin B12 (p<0.01) concentration and mean corpuscular hemoglobin concentration (p<0.05) and positively with TIBC (p<0.01) and HbA1c (p<0.001). Conclusions. Patients and controls differed especially in terms of RDW and TIBC. In studied T1DM children, BMI SDS was associated to iron metabolism parameters and vitamin B12 concentration.http://dx.doi.org/10.1155/2018/5184354 |
| spellingShingle | Ewa Rusak Anna Rotarska-Mizera Piotr Adamczyk Bogdan Mazur Joanna Polanska Agata Chobot Markers of Anemia in Children with Type 1 Diabetes Journal of Diabetes Research |
| title | Markers of Anemia in Children with Type 1 Diabetes |
| title_full | Markers of Anemia in Children with Type 1 Diabetes |
| title_fullStr | Markers of Anemia in Children with Type 1 Diabetes |
| title_full_unstemmed | Markers of Anemia in Children with Type 1 Diabetes |
| title_short | Markers of Anemia in Children with Type 1 Diabetes |
| title_sort | markers of anemia in children with type 1 diabetes |
| url | http://dx.doi.org/10.1155/2018/5184354 |
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