Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection
Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation of symptomatic people is not enough to control...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2024/8871439 |
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| author | Diana Lourdes Padilla-Bórquez Mónica Guadalupe Matuz-Flores Jorge Hernández-Bello Gabriela Athziri Sánchez-Zuno Samuel García-Arellano Edith Oregon-Romero Melva Guadalupe Herrera-Godina Guillermo González-Estevez Norma Patricia Adan-Bante Jesús Alfredo Rosas-Rodríguez José Francisco Muñoz-Valle |
| author_facet | Diana Lourdes Padilla-Bórquez Mónica Guadalupe Matuz-Flores Jorge Hernández-Bello Gabriela Athziri Sánchez-Zuno Samuel García-Arellano Edith Oregon-Romero Melva Guadalupe Herrera-Godina Guillermo González-Estevez Norma Patricia Adan-Bante Jesús Alfredo Rosas-Rodríguez José Francisco Muñoz-Valle |
| author_sort | Diana Lourdes Padilla-Bórquez |
| collection | DOAJ |
| description | Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation of symptomatic people is not enough to control the spread of the disease. Methods. A total of 171 unvaccinated young adults (18–35 years) from Sonora, Mexico, who underwent a structured survey to identify prior COVID-19 infections, were included in this study. A qualitative determination of anti-SARS-CoV-2 antibodies in serum was performed by lateral flow immunoassay (Certum IgG/IgM Rapid Test™ cassette kit) and neutralizing antibodies were also determined (GenScript cPass assay). Results. A total of 36 people reported a history of COVID-19 infection, and 135 reported no history of COVID-19. In contrast, 49.6% (67/135) of individuals who had not reported a previous SARS-CoV-2 infection were seropositive to the rapid anti-SARS-CoV-2 antibody test, and 48.1% (65/135) of them had neutralizing antibodies. Conclusions. These results suggest that in young adults, SARS-CoV-2 infections could be asymptomatic in a high percentage of individuals, which could contribute in part to the slow control of the current pandemic due to the large number of asymptomatic cases that are contagious and that could be a silent spread of the virus. |
| format | Article |
| id | doaj-art-2e55f066dd54435485f3c3fe0f4605ec |
| institution | Kabale University |
| issn | 1918-1493 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-2e55f066dd54435485f3c3fe0f4605ec2025-02-03T07:23:43ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1918-14932024-01-01202410.1155/2024/8871439Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 InfectionDiana Lourdes Padilla-Bórquez0Mónica Guadalupe Matuz-Flores1Jorge Hernández-Bello2Gabriela Athziri Sánchez-Zuno3Samuel García-Arellano4Edith Oregon-Romero5Melva Guadalupe Herrera-Godina6Guillermo González-Estevez7Norma Patricia Adan-Bante8Jesús Alfredo Rosas-Rodríguez9José Francisco Muñoz-Valle10Instituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasInstituto de Investigación en Ciencias BiomédicasDepartamento de Ciencias QuímicasDepartamento de Ciencias QuímicasInstituto de Investigación en Ciencias BiomédicasBackground. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation of symptomatic people is not enough to control the spread of the disease. Methods. A total of 171 unvaccinated young adults (18–35 years) from Sonora, Mexico, who underwent a structured survey to identify prior COVID-19 infections, were included in this study. A qualitative determination of anti-SARS-CoV-2 antibodies in serum was performed by lateral flow immunoassay (Certum IgG/IgM Rapid Test™ cassette kit) and neutralizing antibodies were also determined (GenScript cPass assay). Results. A total of 36 people reported a history of COVID-19 infection, and 135 reported no history of COVID-19. In contrast, 49.6% (67/135) of individuals who had not reported a previous SARS-CoV-2 infection were seropositive to the rapid anti-SARS-CoV-2 antibody test, and 48.1% (65/135) of them had neutralizing antibodies. Conclusions. These results suggest that in young adults, SARS-CoV-2 infections could be asymptomatic in a high percentage of individuals, which could contribute in part to the slow control of the current pandemic due to the large number of asymptomatic cases that are contagious and that could be a silent spread of the virus.http://dx.doi.org/10.1155/2024/8871439 |
| spellingShingle | Diana Lourdes Padilla-Bórquez Mónica Guadalupe Matuz-Flores Jorge Hernández-Bello Gabriela Athziri Sánchez-Zuno Samuel García-Arellano Edith Oregon-Romero Melva Guadalupe Herrera-Godina Guillermo González-Estevez Norma Patricia Adan-Bante Jesús Alfredo Rosas-Rodríguez José Francisco Muñoz-Valle Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection |
| title_full | Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection |
| title_fullStr | Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection |
| title_full_unstemmed | Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection |
| title_short | Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection |
| title_sort | seroprevalence of igm igg and neutralizing antibodies against sars cov 2 in unvaccinated young adults from mexico who reported not having had a previous covid 19 infection |
| url | http://dx.doi.org/10.1155/2024/8871439 |
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