Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys
Biodegradable magnesium (Mg)-based materials show promise for orthopedic implants but continue to face challenges such as limited mechanical strength, rapid corrosion, and insufficient osteogenic performance. Alloying offers a practical solution by improving these properties and mitigating their rap...
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Elsevier
2025-05-01
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| Series: | Journal of Materials Research and Technology |
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| author | Wenyue Yang Xiaomin Chen Hao Gu Li Li Jiaying Gu Yuan Zhang Xiaoyu Gu Chenyuan Zhu Miao Luo Liqiang Wang Changxi Liu Yuanfei Fu |
| author_facet | Wenyue Yang Xiaomin Chen Hao Gu Li Li Jiaying Gu Yuan Zhang Xiaoyu Gu Chenyuan Zhu Miao Luo Liqiang Wang Changxi Liu Yuanfei Fu |
| author_sort | Wenyue Yang |
| collection | DOAJ |
| description | Biodegradable magnesium (Mg)-based materials show promise for orthopedic implants but continue to face challenges such as limited mechanical strength, rapid corrosion, and insufficient osteogenic performance. Alloying offers a practical solution by improving these properties and mitigating their rapid degradation in physiological environments. In this study, we designed novel Mg–Zn–Mn–Ca alloys with 2 wt% and 3 wt% Zn (referred to as Mg2Zn and Mg3Zn), harnessing the synergistic effects of Zn, Mn, and Ca to enhance mechanical properties, corrosion resistance, and biological performance. Both alloys outperformed pure Mg in mechanical tests; notably, Mg3Zn achieved an ultimate tensile strength of 206.5 MPa and an elongation of 30.1 %, underscoring a balance of strength and ductility. Corrosion analysis showed that Mg3Zn had the lowest corrosion rate (1.17 mm/year) and formed compact, insoluble corrosion products. Regarding osteogenic potential, Mg2Zn enhanced Runx2 expression 1.69-fold, while Mg3Zn increased Ocn expression 1.95-fold relative to the control, with Mg3Zn consistently showing higher osteogenic capacity. Altogether, Mg–Zn–Mn–Ca alloys demonstrated enhanced mechanical properties and excellent osteogenic potential, with the 3 wt% Zn alloy providing superior corrosion resistance and mid-to-late-stage osteogenesis. These findings position Mg3Zn as a strong candidate for biodegradable metallic orthopedic implants with significant clinical potential. |
| format | Article |
| id | doaj-art-2e50d97e84394bfd9af93cb66256fd75 |
| institution | DOAJ |
| issn | 2238-7854 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
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| series | Journal of Materials Research and Technology |
| spelling | doaj-art-2e50d97e84394bfd9af93cb66256fd752025-08-20T03:14:35ZengElsevierJournal of Materials Research and Technology2238-78542025-05-01365727574110.1016/j.jmrt.2025.04.217Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloysWenyue Yang0Xiaomin Chen1Hao Gu2Li Li3Jiaying Gu4Yuan Zhang5Xiaoyu Gu6Chenyuan Zhu7Miao Luo8Liqiang Wang9Changxi Liu10Yuanfei Fu11Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, ChinaDepartment of Stomatology, Kunshan Hospital of Traditional Chinese Medicine, 215300, Kunshan, Jiangsu, ChinaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, ChinaCenter for Experimental Materials Science and Engineering Education, Shanghai Jiao Tong University, Shanghai, 200240, ChinaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, ChinaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, ChinaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, China; Department of Dental Technology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, ChinaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, ChinaAffiliated Hospital of Youjiang Medical University for Nationalities, Life Science and Clinical Medicine Research Center, Baise, Guangxi, 33000, China; Corresponding author.State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaState Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, ChinaDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai, 200011, China; Department of Dental Technology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China; Corresponding author. No. 639, Zhizaoju Road, Huangpu District, Shanghai, 200011, China.Biodegradable magnesium (Mg)-based materials show promise for orthopedic implants but continue to face challenges such as limited mechanical strength, rapid corrosion, and insufficient osteogenic performance. Alloying offers a practical solution by improving these properties and mitigating their rapid degradation in physiological environments. In this study, we designed novel Mg–Zn–Mn–Ca alloys with 2 wt% and 3 wt% Zn (referred to as Mg2Zn and Mg3Zn), harnessing the synergistic effects of Zn, Mn, and Ca to enhance mechanical properties, corrosion resistance, and biological performance. Both alloys outperformed pure Mg in mechanical tests; notably, Mg3Zn achieved an ultimate tensile strength of 206.5 MPa and an elongation of 30.1 %, underscoring a balance of strength and ductility. Corrosion analysis showed that Mg3Zn had the lowest corrosion rate (1.17 mm/year) and formed compact, insoluble corrosion products. Regarding osteogenic potential, Mg2Zn enhanced Runx2 expression 1.69-fold, while Mg3Zn increased Ocn expression 1.95-fold relative to the control, with Mg3Zn consistently showing higher osteogenic capacity. Altogether, Mg–Zn–Mn–Ca alloys demonstrated enhanced mechanical properties and excellent osteogenic potential, with the 3 wt% Zn alloy providing superior corrosion resistance and mid-to-late-stage osteogenesis. These findings position Mg3Zn as a strong candidate for biodegradable metallic orthopedic implants with significant clinical potential.http://www.sciencedirect.com/science/article/pii/S2238785425010385MagnesiumBiodegradable implantMg–Zn–Mn–CaCorrosion resistanceOsteogenic ability |
| spellingShingle | Wenyue Yang Xiaomin Chen Hao Gu Li Li Jiaying Gu Yuan Zhang Xiaoyu Gu Chenyuan Zhu Miao Luo Liqiang Wang Changxi Liu Yuanfei Fu Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys Journal of Materials Research and Technology Magnesium Biodegradable implant Mg–Zn–Mn–Ca Corrosion resistance Osteogenic ability |
| title | Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys |
| title_full | Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys |
| title_fullStr | Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys |
| title_full_unstemmed | Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys |
| title_short | Mechanical properties, corrosion resistance, and osteogenic potential of biodegradable Mg–Zn–Mn–Ca alloys |
| title_sort | mechanical properties corrosion resistance and osteogenic potential of biodegradable mg zn mn ca alloys |
| topic | Magnesium Biodegradable implant Mg–Zn–Mn–Ca Corrosion resistance Osteogenic ability |
| url | http://www.sciencedirect.com/science/article/pii/S2238785425010385 |
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