Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair
Abstract Well‐integration of multiple bioactive components into a biological patch without damaging its cellular matrix structure is crucial for infectious abdominal wall defect repair but remains challenging. Herein, a novel asymmetric biological composite patch (bPVA/SIS+‐NP) is developed by in si...
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| Format: | Article |
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202500865 |
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| author | Zeping Huang Weiwen Liang Binying Peng Yang Ouyang Zixin Chen Mawsoom Mamut Zhipeng Huang Hui Wang Rongkang Huang Bo Ma Bingna Zheng Jian Cai |
| author_facet | Zeping Huang Weiwen Liang Binying Peng Yang Ouyang Zixin Chen Mawsoom Mamut Zhipeng Huang Hui Wang Rongkang Huang Bo Ma Bingna Zheng Jian Cai |
| author_sort | Zeping Huang |
| collection | DOAJ |
| description | Abstract Well‐integration of multiple bioactive components into a biological patch without damaging its cellular matrix structure is crucial for infectious abdominal wall defect repair but remains challenging. Herein, a novel asymmetric biological composite patch (bPVA/SIS+‐NP) is developed by in situ introducing zwitterionic polyvinyl alcohol molecular brush (bPVA) hydrogel to a cationic small intestinal submucosal decellularized matrix (SIS+) via a self‐induced phase separation based united strategy. Due to its high hydrogen bonding crosslinking and strong mechanical interlocking with SIS+‐NP layer, bPVA layer can maintain stable anti‐contamination and the corresponding anti‐adhesion properties in the contaminated environment. On the basis of preserving an original extracellular matrix skeleton, SIS+‐NP layer can show strong contact anti‐bacterial ability at the acute stage of repair together with the prolonged drug release during the healing stage of repair. Furthermore, the in situ combination of bPVA and SIS+‐NP layers can lead to a high and stable burst pressure tolerance. By comprehensive control of bacteria and their necrotic products, bPVA/SIS+‐NP patch can achieve anti‐infection, anti‐adhesion, and pro‐healing properties in the infectious abdominal wall defect on rats. Therefore, the bPVA/SIS+‐NP patch opens a new avenue for bio‐friendly construction of multifunctional biological patches to address the stringent requirements of infectious abdominal wall defect repair. |
| format | Article |
| id | doaj-art-2e4dd169c61540fc9c2bad612657ea5e |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Advanced Science |
| spelling | doaj-art-2e4dd169c61540fc9c2bad612657ea5e2025-08-20T02:43:09ZengWileyAdvanced Science2198-38442025-07-011225n/an/a10.1002/advs.202500865Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect RepairZeping Huang0Weiwen Liang1Binying Peng2Yang Ouyang3Zixin Chen4Mawsoom Mamut5Zhipeng Huang6Hui Wang7Rongkang Huang8Bo Ma9Bingna Zheng10Jian Cai11Department of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of UrologyThe First People's Hospital of KashiKashi 844099 P. R. ChinaDepartment of UrologyThe First People's Hospital of KashiKashi 844099 P. R. ChinaDepartment of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of General Surgery (Colorectal Surgery)Guangdong Institute of GastroenterologyBiomedical Innovation CenterGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaDepartment of UrologyThe Sixth Affiliated HospitalSun Yat‐sen UniversityGuangzhou510655P. R. ChinaThe Eighth Affiliated HospitalSun Yat‐sen UniversityShenzhen518000P. R. ChinaDepartment of Colorectal SurgeryShenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen UniversityMedical Innovation Technology Transformation Center of Shenzhen Second People's HospitalShenzhen UniversityShenzhen518035P. R. ChinaAbstract Well‐integration of multiple bioactive components into a biological patch without damaging its cellular matrix structure is crucial for infectious abdominal wall defect repair but remains challenging. Herein, a novel asymmetric biological composite patch (bPVA/SIS+‐NP) is developed by in situ introducing zwitterionic polyvinyl alcohol molecular brush (bPVA) hydrogel to a cationic small intestinal submucosal decellularized matrix (SIS+) via a self‐induced phase separation based united strategy. Due to its high hydrogen bonding crosslinking and strong mechanical interlocking with SIS+‐NP layer, bPVA layer can maintain stable anti‐contamination and the corresponding anti‐adhesion properties in the contaminated environment. On the basis of preserving an original extracellular matrix skeleton, SIS+‐NP layer can show strong contact anti‐bacterial ability at the acute stage of repair together with the prolonged drug release during the healing stage of repair. Furthermore, the in situ combination of bPVA and SIS+‐NP layers can lead to a high and stable burst pressure tolerance. By comprehensive control of bacteria and their necrotic products, bPVA/SIS+‐NP patch can achieve anti‐infection, anti‐adhesion, and pro‐healing properties in the infectious abdominal wall defect on rats. Therefore, the bPVA/SIS+‐NP patch opens a new avenue for bio‐friendly construction of multifunctional biological patches to address the stringent requirements of infectious abdominal wall defect repair.https://doi.org/10.1002/advs.202500865anti‐bacterialanti‐contaminationasymmetric porous patchinfectious abdominal wall defectzwitterionic polyvinyl alcohol molecular brush |
| spellingShingle | Zeping Huang Weiwen Liang Binying Peng Yang Ouyang Zixin Chen Mawsoom Mamut Zhipeng Huang Hui Wang Rongkang Huang Bo Ma Bingna Zheng Jian Cai Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair Advanced Science anti‐bacterial anti‐contamination asymmetric porous patch infectious abdominal wall defect zwitterionic polyvinyl alcohol molecular brush |
| title | Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair |
| title_full | Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair |
| title_fullStr | Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair |
| title_full_unstemmed | Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair |
| title_short | Polymer Brush‐Based Asymmetric Porous Patch with Excellent Anti‐Bacterial and Anti‐Contamination Properties Enables Infectious Abdominal Wall Defect Repair |
| title_sort | polymer brush based asymmetric porous patch with excellent anti bacterial and anti contamination properties enables infectious abdominal wall defect repair |
| topic | anti‐bacterial anti‐contamination asymmetric porous patch infectious abdominal wall defect zwitterionic polyvinyl alcohol molecular brush |
| url | https://doi.org/10.1002/advs.202500865 |
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