Exploiting native forces to capture chromosome conformation in mammalian cell nuclei

Exploiting native forces to capture chromosome conformation in mammalian cell nuclei

Abstract Mammalian interphase chromosomes fold into a multitude of loops to fit the confines of cell nuclei, and looping is tightly linked to regulated function. Chromosome conformation capture (3C) technology has significantly advanced our understanding of this structure‐to‐function relationship. H...

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Bibliographic Details
Main Authors: Lilija Brant, Theodore Georgomanolis, Milos Nikolic, Chris A Brackley, Petros Kolovos, Wilfred van Ijcken, Frank G Grosveld, Davide Marenduzzo, Argyris Papantonis
Format: Article
Language:English
Published: Springer Nature 2016-12-01
Series:Molecular Systems Biology
Subjects:
chromatin looping
chromosome conformation capture
cross‐linking
nuclear compartments
nuclear organization
Online Access:https://doi.org/10.15252/msb.20167311
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