RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
Abstract. In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared with serum levels of pro- and anti-inflammatory factors of immunity, like as with histological features of genital cancer and cervical epi...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/232 |
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| author | A. I. Autenshlus A. P. Lykov A. N. Shcunov N. A. Varaksin D. V. Morozov V. B. Prohozhev E. S. Mikhayllova G. А. Кretinin S. E. Krasillnikov |
| author_facet | A. I. Autenshlus A. P. Lykov A. N. Shcunov N. A. Varaksin D. V. Morozov V. B. Prohozhev E. S. Mikhayllova G. А. Кretinin S. E. Krasillnikov |
| author_sort | A. I. Autenshlus |
| collection | DOAJ |
| description | Abstract. In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared with serum levels of pro- and anti-inflammatory factors of immunity, like as with histological features of genital cancer and cervical epithelial dysplasia. In vitro cellular response was regarded as positive, if relative amounts of CD8-positive lymphocytes increased by > 15% following incubation of blood mononuclears with cancer-associated antigens. Positive reaction and elevated serum levels of anti-TNFα and anti-IFNγ antibodies were associated with lesser malignancy of tumor, as proven by histological findings in the women with genital cancer. A positive cellular reaction was associated with increased serum levels of IFNγ and anti-TNFα in women with grade II–III cervical epithelial dysplasia. It is concluded about potential applicability of testing mononuclears with fetal proteins, to determine a grade of malignancy for the female genital tumors, as well as a degree of regenerative disturbances of cervical epithelium. |
| format | Article |
| id | doaj-art-2e45de629f514fad99b14928cc03df21 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-2e45de629f514fad99b14928cc03df212025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0194-551351810.15789/1563-0625-2007-4-5-513-518229RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIAA. I. Autenshlus0A. P. Lykov1A. N. Shcunov2N. A. Varaksin3D. V. Morozov4V. B. Prohozhev5E. S. Mikhayllova6G. А. Кretinin7S. E. Krasillnikov8Институт молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскИнститут молекулярной биологии и биофизики СО РАМН, г. НовосибирскAbstract. In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared with serum levels of pro- and anti-inflammatory factors of immunity, like as with histological features of genital cancer and cervical epithelial dysplasia. In vitro cellular response was regarded as positive, if relative amounts of CD8-positive lymphocytes increased by > 15% following incubation of blood mononuclears with cancer-associated antigens. Positive reaction and elevated serum levels of anti-TNFα and anti-IFNγ antibodies were associated with lesser malignancy of tumor, as proven by histological findings in the women with genital cancer. A positive cellular reaction was associated with increased serum levels of IFNγ and anti-TNFα in women with grade II–III cervical epithelial dysplasia. It is concluded about potential applicability of testing mononuclears with fetal proteins, to determine a grade of malignancy for the female genital tumors, as well as a degree of regenerative disturbances of cervical epithelium.https://www.mimmun.ru/mimmun/article/view/232mononuclear cellsantigenscytokinesantibodiescancerepithelial dysplasia |
| spellingShingle | A. I. Autenshlus A. P. Lykov A. N. Shcunov N. A. Varaksin D. V. Morozov V. B. Prohozhev E. S. Mikhayllova G. А. Кretinin S. E. Krasillnikov RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA Медицинская иммунология mononuclear cells antigens cytokines antibodies cancer epithelial dysplasia |
| title | RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA |
| title_full | RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA |
| title_fullStr | RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA |
| title_full_unstemmed | RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA |
| title_short | RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA |
| title_sort | response of mononuclear cells to cancer associated antigens humoral factors of immunity and pathohistological findings in women with genital malignancies cervical epithelial dysplasia |
| topic | mononuclear cells antigens cytokines antibodies cancer epithelial dysplasia |
| url | https://www.mimmun.ru/mimmun/article/view/232 |
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