Assessment and discussion of quality monitoring data for red blood cell preparations
[Objective] To assess the data characteristics of quality monitoring indicators for red blood cell (RBC) preparations, so as to provide reference for continuous improvement of blood quality. [Methods] The quality inspection data of 6 types of RBC preparations from Chongqing blood center from 2019 to...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-02-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.02.011&lang=en |
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| _version_ | 1849762758601474048 |
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| author | QING Yun DAI Huayou YANG Junhong XU Qian WU Siqi TIAN Yunbo HUANG Xia |
| author_facet | QING Yun DAI Huayou YANG Junhong XU Qian WU Siqi TIAN Yunbo HUANG Xia |
| author_sort | QING Yun |
| collection | DOAJ |
| description | [Objective] To assess the data characteristics of quality monitoring indicators for red blood cell (RBC) preparations, so as to provide reference for continuous improvement of blood quality. [Methods] The quality inspection data of 6 types of RBC preparations from Chongqing blood center from 2019 to 2023 were summarized. For the same indicators, the numerical range of quality indicators was monitored by comparing different types of preparations with the national standard GB18469. The loss and/or damage to RBCs caused by different preparation process were compared, and the impact of different preparation processes on the quality of RBCs was discussed. [Results] The appearance and sterility test compliance rates of the six types of RBC preparations were both 100%, while the compliance rates of other items were all ≥75%. The compliance rate of hematocrit for suspended RBCs was the lowest at 75%, with a median of 0.52, which was close to the lower limit of GB18469, while the medians of hematocrit for the other types were all at the midline level of GB18469. The Hb content for different types of RBCs was significantly higher than the corresponding requirements of GB18469 (P<0.05). The hemolysis rate at the end of storage for different types of RBCs was significantly lower than the requirements of GB18469 (P<0.05). The 1 U leukoreduction process resulted in a hemoglobin content loss of about 5% and had a significant impact on the hemolysis rate at the end of storage (P<0.05). The washing process resulted in a hemoglobin content loss of <3% and had no significant impact on the hemolysis rate at the end of storage (P>0.05). The concentration process resulted in a hemoglobin content loss of <3% and had a significant impact on the hemolysis rate at the end of storage (P<0.05). [Conclusion] The impact of different processes on RBC preparations is within a controllable range and meets the requirements of GB18469. The quality monitoring data can provide a reference for clinical blood selection, effectiveness evaluation and revision of related standards. |
| format | Article |
| id | doaj-art-2e4571e14d9a4104b4eaae3882a04d27 |
| institution | DOAJ |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-2e4571e14d9a4104b4eaae3882a04d272025-08-20T03:05:39ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-02-0138222723210.13303/j.cjbt.issn.1004-549x.2025.02.0111004-549X(2025)2-0227-07Assessment and discussion of quality monitoring data for red blood cell preparationsQING Yun0DAI Huayou1YANG Junhong2XU Qian3WU Siqi4TIAN Yunbo5HUANG Xia6Chongqing Blood Center, Chongqing 400052, ChinaChongqing Blood Center, Chongqing 400052, ChinaChongqing Blood Center, Chongqing 400052, ChinaChongqing Blood Center, Chongqing 400052, ChinaChongqing Blood Center, Chongqing 400052, ChinaChongqing Blood Center, Chongqing 400052, ChinaChongqing Blood Center, Chongqing 400052, China[Objective] To assess the data characteristics of quality monitoring indicators for red blood cell (RBC) preparations, so as to provide reference for continuous improvement of blood quality. [Methods] The quality inspection data of 6 types of RBC preparations from Chongqing blood center from 2019 to 2023 were summarized. For the same indicators, the numerical range of quality indicators was monitored by comparing different types of preparations with the national standard GB18469. The loss and/or damage to RBCs caused by different preparation process were compared, and the impact of different preparation processes on the quality of RBCs was discussed. [Results] The appearance and sterility test compliance rates of the six types of RBC preparations were both 100%, while the compliance rates of other items were all ≥75%. The compliance rate of hematocrit for suspended RBCs was the lowest at 75%, with a median of 0.52, which was close to the lower limit of GB18469, while the medians of hematocrit for the other types were all at the midline level of GB18469. The Hb content for different types of RBCs was significantly higher than the corresponding requirements of GB18469 (P<0.05). The hemolysis rate at the end of storage for different types of RBCs was significantly lower than the requirements of GB18469 (P<0.05). The 1 U leukoreduction process resulted in a hemoglobin content loss of about 5% and had a significant impact on the hemolysis rate at the end of storage (P<0.05). The washing process resulted in a hemoglobin content loss of <3% and had no significant impact on the hemolysis rate at the end of storage (P>0.05). The concentration process resulted in a hemoglobin content loss of <3% and had a significant impact on the hemolysis rate at the end of storage (P<0.05). [Conclusion] The impact of different processes on RBC preparations is within a controllable range and meets the requirements of GB18469. The quality monitoring data can provide a reference for clinical blood selection, effectiveness evaluation and revision of related standards.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.02.011&lang=enred blood cells (rbcs)blood componentsquality variabilityquality controlgb18469 |
| spellingShingle | QING Yun DAI Huayou YANG Junhong XU Qian WU Siqi TIAN Yunbo HUANG Xia Assessment and discussion of quality monitoring data for red blood cell preparations Zhongguo shuxue zazhi red blood cells (rbcs) blood components quality variability quality control gb18469 |
| title | Assessment and discussion of quality monitoring data for red blood cell preparations |
| title_full | Assessment and discussion of quality monitoring data for red blood cell preparations |
| title_fullStr | Assessment and discussion of quality monitoring data for red blood cell preparations |
| title_full_unstemmed | Assessment and discussion of quality monitoring data for red blood cell preparations |
| title_short | Assessment and discussion of quality monitoring data for red blood cell preparations |
| title_sort | assessment and discussion of quality monitoring data for red blood cell preparations |
| topic | red blood cells (rbcs) blood components quality variability quality control gb18469 |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.02.011&lang=en |
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