Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling
Cardiac hypertrophy entails complex structural remodeling involving rearrangement of muscle fibers, interstitial fibrosis, accumulation of extracellular matrix, and angiogenesis. Many of the processes unde...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/535241 |
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| _version_ | 1850106486469951488 |
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| author | Norifumi Takeda Ichiro Manabe |
| author_facet | Norifumi Takeda Ichiro Manabe |
| author_sort | Norifumi Takeda |
| collection | DOAJ |
| description | Cardiac hypertrophy
entails complex structural remodeling involving
rearrangement of muscle fibers, interstitial
fibrosis, accumulation of extracellular matrix,
and angiogenesis. Many of the processes
underlying cardiac remodeling have features in
common with chronic inflammatory processes.
During these processes, nonmyocytes, such as
endothelial cells, fibroblasts, and immune cells,
residing in or infiltrating into the myocardial
interstitium play active roles. This paper
mainly addresses the functional roles of
nonmyocytes during cardiac remodeling. In
particular, we focus on the communication
between cardiomyocytes and nonmyocytes through
direct cell-cell interactions and
autocrine/paracrine-mediated
pathways. |
| format | Article |
| id | doaj-art-2e44b1ffd6e44d2dac7f82f0d54c2553 |
| institution | OA Journals |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-2e44b1ffd6e44d2dac7f82f0d54c25532025-08-20T02:38:49ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/535241535241Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac RemodelingNorifumi Takeda0Ichiro Manabe1Department of Cell and Developmental Biology and Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, JapanCardiac hypertrophy entails complex structural remodeling involving rearrangement of muscle fibers, interstitial fibrosis, accumulation of extracellular matrix, and angiogenesis. Many of the processes underlying cardiac remodeling have features in common with chronic inflammatory processes. During these processes, nonmyocytes, such as endothelial cells, fibroblasts, and immune cells, residing in or infiltrating into the myocardial interstitium play active roles. This paper mainly addresses the functional roles of nonmyocytes during cardiac remodeling. In particular, we focus on the communication between cardiomyocytes and nonmyocytes through direct cell-cell interactions and autocrine/paracrine-mediated pathways.http://dx.doi.org/10.4061/2011/535241 |
| spellingShingle | Norifumi Takeda Ichiro Manabe Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling International Journal of Inflammation |
| title | Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling |
| title_full | Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling |
| title_fullStr | Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling |
| title_full_unstemmed | Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling |
| title_short | Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling |
| title_sort | cellular interplay between cardiomyocytes and nonmyocytes in cardiac remodeling |
| url | http://dx.doi.org/10.4061/2011/535241 |
| work_keys_str_mv | AT norifumitakeda cellularinterplaybetweencardiomyocytesandnonmyocytesincardiacremodeling AT ichiromanabe cellularinterplaybetweencardiomyocytesandnonmyocytesincardiacremodeling |