Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis
IntroductionLupus nephritis (LN) is a severe complication of systemic lupus erythematosus, often leading to end-stage kidney disease. Serum sulfatide levels are linked to severe kidney vasculitis. This study aimed to assess serum sulfatide levels as a marker for classifying and evaluating disease ac...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571147/full |
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| author | Kosuke Yamaka Daiki Aomura Makoto Harada Takero Nakajima Takayuki Nimura Koji Hashimoto Naoki Tanaka Naoki Tanaka Naoki Tanaka Yuji Kamijo |
| author_facet | Kosuke Yamaka Daiki Aomura Makoto Harada Takero Nakajima Takayuki Nimura Koji Hashimoto Naoki Tanaka Naoki Tanaka Naoki Tanaka Yuji Kamijo |
| author_sort | Kosuke Yamaka |
| collection | DOAJ |
| description | IntroductionLupus nephritis (LN) is a severe complication of systemic lupus erythematosus, often leading to end-stage kidney disease. Serum sulfatide levels are linked to severe kidney vasculitis. This study aimed to assess serum sulfatide levels as a marker for classifying and evaluating disease activity in LN.MethodsWe conducted a retrospective study of patients admitted to our hospital between 2003 and 2022. Serum sulfatide levels were compared between LN patients and controls as well as across LN classes based on the International Society of Nephrology/Renal Pathology Society classification. We also analyzed the association between sulfatide levels and active lesions, the Activity Index, and its components.ResultsSerum sulfatide levels were significantly lower in LN patients than in controls (6.90 ± 2.22 vs. 8.34 ± 1.68, P = 0.007). Levels across LN classes were as follows: 9.41 nmol/mL in Class I, 8.21 ± 1.68 nmol/mL in Class II, 7.33 ± 2.25 nmol/mL in Class III, 6.14 ± 1.63 nmol/mL in Class IV, and 7.89 ± 2.12 nmol/mL in Class V, with Class IV having the lowest levels. Serum sulfatides were significantly lower in patients with active lesions (6.38 ± 1.81 vs. 8.23 ± 2.55, P = 0.006) and negatively correlated with the Activity Index (r = −0.51, P < 0.001) and pathological components such as endocapillary hypercellularity, neutrophils/karyorrhexis, and interstitial inflammation (P < 0.001).ConclusionsSerum sulfatide levels were significantly lower in LN patients than in controls and strongly correlated with active lesions and the Activity Index. These findings suggest sulfatide levels as a useful marker for assessing LN disease activity. |
| format | Article |
| id | doaj-art-2e3f754ae6e549d39ecc9759f60a56df |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-2e3f754ae6e549d39ecc9759f60a56df2025-08-20T03:45:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.15711471571147Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritisKosuke Yamaka0Daiki Aomura1Makoto Harada2Takero Nakajima3Takayuki Nimura4Koji Hashimoto5Naoki Tanaka6Naoki Tanaka7Naoki Tanaka8Yuji Kamijo9Department of Nephrology, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Nephrology, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Nephrology, Shinshu University School of Medicine, Matsumoto, JapanCenter for Medical Education and Clinical Training, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Nephrology, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Nephrology, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Global Medical Research Promotion, Shinshu University School of Medicine, Matsumoto, JapanInternational Relations Office, Shinshu University School of Medicine, Matsumoto, JapanResearch Center for Social Systems, Shinshu University School of Medicine, Matsumoto, JapanDepartment of Nephrology, Shinshu University School of Medicine, Matsumoto, JapanIntroductionLupus nephritis (LN) is a severe complication of systemic lupus erythematosus, often leading to end-stage kidney disease. Serum sulfatide levels are linked to severe kidney vasculitis. This study aimed to assess serum sulfatide levels as a marker for classifying and evaluating disease activity in LN.MethodsWe conducted a retrospective study of patients admitted to our hospital between 2003 and 2022. Serum sulfatide levels were compared between LN patients and controls as well as across LN classes based on the International Society of Nephrology/Renal Pathology Society classification. We also analyzed the association between sulfatide levels and active lesions, the Activity Index, and its components.ResultsSerum sulfatide levels were significantly lower in LN patients than in controls (6.90 ± 2.22 vs. 8.34 ± 1.68, P = 0.007). Levels across LN classes were as follows: 9.41 nmol/mL in Class I, 8.21 ± 1.68 nmol/mL in Class II, 7.33 ± 2.25 nmol/mL in Class III, 6.14 ± 1.63 nmol/mL in Class IV, and 7.89 ± 2.12 nmol/mL in Class V, with Class IV having the lowest levels. Serum sulfatides were significantly lower in patients with active lesions (6.38 ± 1.81 vs. 8.23 ± 2.55, P = 0.006) and negatively correlated with the Activity Index (r = −0.51, P < 0.001) and pathological components such as endocapillary hypercellularity, neutrophils/karyorrhexis, and interstitial inflammation (P < 0.001).ConclusionsSerum sulfatide levels were significantly lower in LN patients than in controls and strongly correlated with active lesions and the Activity Index. These findings suggest sulfatide levels as a useful marker for assessing LN disease activity.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571147/fulllupus nephritissulfatidessphingolipidssystemic lupus erythematosusvasculitis |
| spellingShingle | Kosuke Yamaka Daiki Aomura Makoto Harada Takero Nakajima Takayuki Nimura Koji Hashimoto Naoki Tanaka Naoki Tanaka Naoki Tanaka Yuji Kamijo Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis Frontiers in Immunology lupus nephritis sulfatides sphingolipids systemic lupus erythematosus vasculitis |
| title | Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis |
| title_full | Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis |
| title_fullStr | Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis |
| title_full_unstemmed | Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis |
| title_short | Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis |
| title_sort | potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis |
| topic | lupus nephritis sulfatides sphingolipids systemic lupus erythematosus vasculitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571147/full |
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