The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that significantly impacts women’s reproductive capabilities and metabolic health, leading to a range of complications that can affect their quality of life. Recent studies have highlighted mitochondrial dysfunction as a crucial fact...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2025-07-01
|
| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/14/7/EC-25-0186.xml |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849317967955755008 |
|---|---|
| author | Xuejun Yan Dan Ma Rongnian Li Jing Xu Ying Zou Minmin He |
| author_facet | Xuejun Yan Dan Ma Rongnian Li Jing Xu Ying Zou Minmin He |
| author_sort | Xuejun Yan |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that significantly impacts women’s reproductive capabilities and metabolic health, leading to a range of complications that can affect their quality of life. Recent studies have highlighted mitochondrial dysfunction as a crucial factor in the complex pathogenesis of PCOS, suggesting that the health of these cellular powerhouses plays a pivotal role in the condition. This review meticulously examines the effects of mitochondrial dysfunction specifically in ovarian granulosa cells, delving into the intricate mechanisms of action that contribute to the development and progression of PCOS, as well as identifying potential therapeutic targets that could be explored for effective treatment. By thoroughly analyzing the relevant literature and synthesizing findings from various studies, this paper aims to provide new insights into the multifaceted nature of PCOS research and promote advancements in clinical treatment strategies that could ultimately improve the health and well-being of women affected by this disorder. |
| format | Article |
| id | doaj-art-2e3e257916a64c048d0e9c9b7eaa1d88 |
| institution | Kabale University |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj-art-2e3e257916a64c048d0e9c9b7eaa1d882025-08-20T03:51:03ZengBioscientificaEndocrine Connections2049-36142025-07-0114710.1530/EC-25-01861The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndromeXuejun Yan0Dan Ma1Rongnian Li2Jing Xu3Ying Zou4Minmin He5NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, ChinaNHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, ChinaXiangtan Hospital of Traditional Chinese Medicine, Xiangtan, Hunan, ChinaNHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, ChinaNHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, ChinaNHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, ChinaPolycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that significantly impacts women’s reproductive capabilities and metabolic health, leading to a range of complications that can affect their quality of life. Recent studies have highlighted mitochondrial dysfunction as a crucial factor in the complex pathogenesis of PCOS, suggesting that the health of these cellular powerhouses plays a pivotal role in the condition. This review meticulously examines the effects of mitochondrial dysfunction specifically in ovarian granulosa cells, delving into the intricate mechanisms of action that contribute to the development and progression of PCOS, as well as identifying potential therapeutic targets that could be explored for effective treatment. By thoroughly analyzing the relevant literature and synthesizing findings from various studies, this paper aims to provide new insights into the multifaceted nature of PCOS research and promote advancements in clinical treatment strategies that could ultimately improve the health and well-being of women affected by this disorder.https://ec.bioscientifica.com/view/journals/ec/14/7/EC-25-0186.xmlmitochondrial dysfunctionpolycystic ovary syndrome (pcos)ovarian granulosa cellsoxidative stresstherapeutic strategies |
| spellingShingle | Xuejun Yan Dan Ma Rongnian Li Jing Xu Ying Zou Minmin He The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome Endocrine Connections mitochondrial dysfunction polycystic ovary syndrome (pcos) ovarian granulosa cells oxidative stress therapeutic strategies |
| title | The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome |
| title_full | The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome |
| title_fullStr | The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome |
| title_full_unstemmed | The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome |
| title_short | The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome |
| title_sort | role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome |
| topic | mitochondrial dysfunction polycystic ovary syndrome (pcos) ovarian granulosa cells oxidative stress therapeutic strategies |
| url | https://ec.bioscientifica.com/view/journals/ec/14/7/EC-25-0186.xml |
| work_keys_str_mv | AT xuejunyan theroleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT danma theroleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT rongnianli theroleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT jingxu theroleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT yingzou theroleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT minminhe theroleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT xuejunyan roleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT danma roleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT rongnianli roleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT jingxu roleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT yingzou roleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome AT minminhe roleofmitochondrialdysfunctioninovariangranulosacellsinpolycysticovarysyndrome |