Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer
Inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Chronic inflammation plays a critical role in tumorigenesis. Tumor infiltrating inflammatory cells mediate processes associated with progression, immune suppression, promotion of neoangiogenesis and...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3494608 |
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| _version_ | 1850106555626684416 |
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| author | Mario Orozco-Morales Giovanny Soca-Chafre Pedro Barrios-Bernal Norma Hernández-Pedro Oscar Arrieta |
| author_facet | Mario Orozco-Morales Giovanny Soca-Chafre Pedro Barrios-Bernal Norma Hernández-Pedro Oscar Arrieta |
| author_sort | Mario Orozco-Morales |
| collection | DOAJ |
| description | Inflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Chronic inflammation plays a critical role in tumorigenesis. Tumor infiltrating inflammatory cells mediate processes associated with progression, immune suppression, promotion of neoangiogenesis and lymphangiogenesis, remodeling of extracellular matrix, invasion and metastasis, and, lastly, the inhibition of vaccine-induced antitumor T cell response. Accumulating evidence indicates a critical role of myeloid cells in the pathophysiology of human cancers. In contrast to the well-characterized tumor-associated macrophages (TAMs), the significance of granulocytes in cancer has only recently begun to emerge with the characterization of tumor-associated neutrophils (TANs). Recent studies show the importance of CD47 in the interaction with macrophages inhibiting phagocytosis and promoting the migration of neutrophils, increasing inflammation which can lead to recurrence and progression in lung cancer. Currently, therapies are targeted towards blocking CD47 and enhancing macrophage-mediated phagocytosis. However, antibody-based therapies may have adverse effects that limit its use. |
| format | Article |
| id | doaj-art-2e3802bde1274bd48dbf433faaa96b1f |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2e3802bde1274bd48dbf433faaa96b1f2025-08-20T02:38:48ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/34946083494608Interplay between Cellular and Molecular Inflammatory Mediators in Lung CancerMario Orozco-Morales0Giovanny Soca-Chafre1Pedro Barrios-Bernal2Norma Hernández-Pedro3Oscar Arrieta4Experimental Oncology Laboratory, National Cancer Institute of Mexico (INCan), 14080 Mexico, DF, MexicoExperimental Oncology Laboratory, National Cancer Institute of Mexico (INCan), 14080 Mexico, DF, MexicoExperimental Oncology Laboratory, National Cancer Institute of Mexico (INCan), 14080 Mexico, DF, MexicoExperimental Oncology Laboratory, National Cancer Institute of Mexico (INCan), 14080 Mexico, DF, MexicoExperimental Oncology Laboratory, National Cancer Institute of Mexico (INCan), 14080 Mexico, DF, MexicoInflammation is a component of the tumor microenvironment and represents the 7th hallmark of cancer. Chronic inflammation plays a critical role in tumorigenesis. Tumor infiltrating inflammatory cells mediate processes associated with progression, immune suppression, promotion of neoangiogenesis and lymphangiogenesis, remodeling of extracellular matrix, invasion and metastasis, and, lastly, the inhibition of vaccine-induced antitumor T cell response. Accumulating evidence indicates a critical role of myeloid cells in the pathophysiology of human cancers. In contrast to the well-characterized tumor-associated macrophages (TAMs), the significance of granulocytes in cancer has only recently begun to emerge with the characterization of tumor-associated neutrophils (TANs). Recent studies show the importance of CD47 in the interaction with macrophages inhibiting phagocytosis and promoting the migration of neutrophils, increasing inflammation which can lead to recurrence and progression in lung cancer. Currently, therapies are targeted towards blocking CD47 and enhancing macrophage-mediated phagocytosis. However, antibody-based therapies may have adverse effects that limit its use.http://dx.doi.org/10.1155/2016/3494608 |
| spellingShingle | Mario Orozco-Morales Giovanny Soca-Chafre Pedro Barrios-Bernal Norma Hernández-Pedro Oscar Arrieta Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer Mediators of Inflammation |
| title | Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer |
| title_full | Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer |
| title_fullStr | Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer |
| title_full_unstemmed | Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer |
| title_short | Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer |
| title_sort | interplay between cellular and molecular inflammatory mediators in lung cancer |
| url | http://dx.doi.org/10.1155/2016/3494608 |
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