Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy
Background: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease (CKD) worldwide. Objective: To evaluate serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy. Methods: A cross-sectional analytical study was conducted at the Department of Nephr...
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Shalamar Medical & Dental College, Lahore, Pakistan
2025-06-01
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| Series: | Journal of Shalamar Medical & Dental College |
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| Online Access: | https://journal.smdc.edu.pk/index.php/journal/article/view/294 |
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| author | Aqsa Fatima Pooran Mal Zoheb Rafique Memon Mukesh Kumar Haseeb Jameel Memon, Misbah Fatima |
| author_facet | Aqsa Fatima Pooran Mal Zoheb Rafique Memon Mukesh Kumar Haseeb Jameel Memon, Misbah Fatima |
| author_sort | Aqsa Fatima |
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Background: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease (CKD) worldwide.
Objective: To evaluate serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy.
Methods: A cross-sectional analytical study was conducted at the Department of Nephrology, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan, from 10th March to 9th September 2023. Patients with type 2 diabetes (T2D) for more than five years, both males and females, 30 to 65 years of age, and with nephropathy for the last 2 years were included in the study. Serum creatinine, serum Cystatin C (Cys-C), fasting blood sugar (FBS), glycated hemoglobin A1c (HbA1c), total protein, and albumin were measured. A spot urine sample was collected to analyze total urinary protein, albumin, and creatinine levels. The estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration (CKD-EPI) equation. One-way ANOVA, Pearson correlation test, and Linear regression analysis were done to analyze the data.
Results: A total of 113 patients were analyzed, with a mean age of 55.5±6.1 years. The mean duration of T2D was 12.0±5.3 years. The mean HbA1c level was 9.1±1.3%. Based on Cys-C levels, the mean eGFR was 71.33±24.8 mL/min/1.73m². Among the participants, 43(38.1%), were suffering from Stage II, 32(28.3%) from Stage I, 32(28.3%) from Stage III, and 6(5.3%) from Stage IV CKD. A majority of 50(44.2%) of study participants had microalbuminuria. A statistically significant (p<0.001) negative correlation between eGFR and Cys-C level was observed among the study participants. Serum Cystatin C is a significant (<0.05) predictor of eGFR.
Conclusion: Serum Cystatin C was a significant predictor of eGFR in type 2 diabetic patients with nephropathy. The strong negative relationship between Cystatin C and eGFR supports its potential role as a valuable marker for assessing renal function in diabetic patients.
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| format | Article |
| id | doaj-art-2e2f7ab9ca8e4dcc8b59f40948368882 |
| institution | Kabale University |
| issn | 2789-3669 2789-3677 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Shalamar Medical & Dental College, Lahore, Pakistan |
| record_format | Article |
| series | Journal of Shalamar Medical & Dental College |
| spelling | doaj-art-2e2f7ab9ca8e4dcc8b59f409483688822025-08-20T03:24:14ZengShalamar Medical & Dental College, Lahore, PakistanJournal of Shalamar Medical & Dental College2789-36692789-36772025-06-016110.53685/jshmdc.v6i1.294Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathyAqsa Fatima0Pooran Mal1Zoheb Rafique Memon2Mukesh Kumar3Haseeb Jameel Memon, 4Misbah Fatima5Department of Nephrology, Liaquat University and Medical Health Sciences, Hyderabad & Jamshoro, PakistanDepartment of Nephrology, Liaquat University and Medical Health Sciences, Hyderabad & Jamshoro, PakistanDepartment of Community Medicine, Liaquat University and Medical Health Sciences, Hyderabad & Jamshoro, PakistanDepartment of Nephrology, Liaquat University and Medical Health Sciences, Hyderabad & Jamshoro, PakistanDepartment of Nephrology, Liaquat University and Medical Health Sciences, Hyderabad & Jamshoro, PakistanDepartment of Nephrology, Abbasi Shaheed Hospital, Karachi, Pakistan Background: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease (CKD) worldwide. Objective: To evaluate serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy. Methods: A cross-sectional analytical study was conducted at the Department of Nephrology, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan, from 10th March to 9th September 2023. Patients with type 2 diabetes (T2D) for more than five years, both males and females, 30 to 65 years of age, and with nephropathy for the last 2 years were included in the study. Serum creatinine, serum Cystatin C (Cys-C), fasting blood sugar (FBS), glycated hemoglobin A1c (HbA1c), total protein, and albumin were measured. A spot urine sample was collected to analyze total urinary protein, albumin, and creatinine levels. The estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration (CKD-EPI) equation. One-way ANOVA, Pearson correlation test, and Linear regression analysis were done to analyze the data. Results: A total of 113 patients were analyzed, with a mean age of 55.5±6.1 years. The mean duration of T2D was 12.0±5.3 years. The mean HbA1c level was 9.1±1.3%. Based on Cys-C levels, the mean eGFR was 71.33±24.8 mL/min/1.73m². Among the participants, 43(38.1%), were suffering from Stage II, 32(28.3%) from Stage I, 32(28.3%) from Stage III, and 6(5.3%) from Stage IV CKD. A majority of 50(44.2%) of study participants had microalbuminuria. A statistically significant (p<0.001) negative correlation between eGFR and Cys-C level was observed among the study participants. Serum Cystatin C is a significant (<0.05) predictor of eGFR. Conclusion: Serum Cystatin C was a significant predictor of eGFR in type 2 diabetic patients with nephropathy. The strong negative relationship between Cystatin C and eGFR supports its potential role as a valuable marker for assessing renal function in diabetic patients. https://journal.smdc.edu.pk/index.php/journal/article/view/294Cystatin CGlomerular Filtration RateDiabetic NephropathyType 2 Diabetes |
| spellingShingle | Aqsa Fatima Pooran Mal Zoheb Rafique Memon Mukesh Kumar Haseeb Jameel Memon, Misbah Fatima Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy Journal of Shalamar Medical & Dental College Cystatin C Glomerular Filtration Rate Diabetic Nephropathy Type 2 Diabetes |
| title | Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy |
| title_full | Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy |
| title_fullStr | Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy |
| title_full_unstemmed | Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy |
| title_short | Evaluation of serum Cystatin C as a predictor of eGFR in type 2 diabetic patients with nephropathy |
| title_sort | evaluation of serum cystatin c as a predictor of egfr in type 2 diabetic patients with nephropathy |
| topic | Cystatin C Glomerular Filtration Rate Diabetic Nephropathy Type 2 Diabetes |
| url | https://journal.smdc.edu.pk/index.php/journal/article/view/294 |
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