The Impact of the Myeloid Response to Radiation Therapy
Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. As has been discussed elsewhere, radiation provides debulking, antigen and adjuvant release, and inflammatory targeting of effector cells to the treatment site, thereby as...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/281958 |
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| _version_ | 1832549084039217152 |
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| author | Michael J. Gough Kristina Young Marka Crittenden |
| author_facet | Michael J. Gough Kristina Young Marka Crittenden |
| author_sort | Michael J. Gough |
| collection | DOAJ |
| description | Radiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. As has been discussed elsewhere, radiation provides debulking, antigen and adjuvant release, and inflammatory targeting of effector cells to the treatment site, thereby assisting multiple critical checkpoints in antitumor adaptive immunity. Adaptive immunity is terminated by inflammatory resolution, an active process which ensures that inflammatory damage is repaired and tissue function is restored. We discuss how radiation therapy similarly triggers inflammation followed by repair, the consequences to adaptive immune responses in the treatment site, and how the myeloid response to radiation may impact immunotherapies designed to improve control of residual cancer cells. |
| format | Article |
| id | doaj-art-2e2e4ce7ecbe45038f624d5ae6e0d2c9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2e2e4ce7ecbe45038f624d5ae6e0d2c92025-02-03T06:12:14ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/281958281958The Impact of the Myeloid Response to Radiation TherapyMichael J. Gough0Kristina Young1Marka Crittenden2Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, 4805 NE Glisan, Portland, OR 97213, USAThe Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USAEarle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, 4805 NE Glisan, Portland, OR 97213, USARadiation therapy is showing potential as a partner for immunotherapies in preclinical cancer models and early clinical studies. As has been discussed elsewhere, radiation provides debulking, antigen and adjuvant release, and inflammatory targeting of effector cells to the treatment site, thereby assisting multiple critical checkpoints in antitumor adaptive immunity. Adaptive immunity is terminated by inflammatory resolution, an active process which ensures that inflammatory damage is repaired and tissue function is restored. We discuss how radiation therapy similarly triggers inflammation followed by repair, the consequences to adaptive immune responses in the treatment site, and how the myeloid response to radiation may impact immunotherapies designed to improve control of residual cancer cells.http://dx.doi.org/10.1155/2013/281958 |
| spellingShingle | Michael J. Gough Kristina Young Marka Crittenden The Impact of the Myeloid Response to Radiation Therapy Clinical and Developmental Immunology |
| title | The Impact of the Myeloid Response to Radiation Therapy |
| title_full | The Impact of the Myeloid Response to Radiation Therapy |
| title_fullStr | The Impact of the Myeloid Response to Radiation Therapy |
| title_full_unstemmed | The Impact of the Myeloid Response to Radiation Therapy |
| title_short | The Impact of the Myeloid Response to Radiation Therapy |
| title_sort | impact of the myeloid response to radiation therapy |
| url | http://dx.doi.org/10.1155/2013/281958 |
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