Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms

IntroductionUlcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by mucosal damage and impaired epithelial barrier function. While glycyl-l-histidyl-l-lysine-copper (GHK-Cu) exhibits known anti-inflammatory properties, its therapeutic mechanisms in UC remain undefined....

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Bibliographic Details
Main Authors: Shuzhen Mao, Jiahui Huang, Junyan Li, Fang Sun, Qilian Zhang, Qing Cheng, Wei Zeng, Dongya Lei, Shiyan Wang, Jing Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
ulcerative colitis
GHK-Cu
SIRT1/STAT3 pathway
co-culture system
network pharmacology
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1551843/full
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