Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State
Alterations in serum levels of trace elements reported in type 2 diabetes mellitus (T2DM) have been linked with induction of T2DM and associated complications. This study was carried out to evaluate the levels of Zinc (Zn), Copper (Cu), Selenium (Se), Lead (Pb) and Cadmium (Cd) in different haptoglo...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hammer Head Production Limited
2024-01-01
|
| Series: | Sokoto Journal of Medical Laboratory Science |
| Subjects: | |
| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/405 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850056449758068736 |
|---|---|
| author | Odewusi, O.O., Overah, D.O., Obadire, S.O., Omon, E.A., Sokunbi, Z.T. |
| author_facet | Odewusi, O.O., Overah, D.O., Obadire, S.O., Omon, E.A., Sokunbi, Z.T. |
| author_sort | Odewusi, O.O., Overah, D.O., Obadire, S.O., Omon, E.A., Sokunbi, Z.T. |
| collection | DOAJ |
| description | Alterations in serum levels of trace elements reported in type 2 diabetes mellitus (T2DM) have been linked with induction of T2DM and associated complications. This study was carried out to evaluate the levels of Zinc (Zn), Copper (Cu), Selenium (Se), Lead (Pb) and Cadmium (Cd) in different haptoglobin phenotypes of complicated and uncomplicated diabetic patients. A total of 100 samples comprising of 30 apparently healthy subjects (control), 39 treated and untreated uncomplicated diabetic patients and 31 hypertensive type 2 diabetic patients were recruited for this study. Characterization of serum haptoglobin phenotypes was determined using protein electrophoresis, while Zn, Cu, Se, Pb and Cd were estimated using Atomic Absorption Spectrometry. Results obtained showed that Pb and Cd levels were significantly higher (p<0.05) in treated complicated diabetes subjects compared to control, while glucose, Zn, Se and Cu levels were non-significant (p>0.05). BMI, glucose, Pb and Cd were significantly higher (p<0.05), while Se and Zn were significantly lower (p<0.05) in untreated complicated diabetes subjects compared to control. Cu was non-significantly lower (p>0.05) in untreated complicated diabetes subjects compared to control. The results also showed that Cu, Se, Pb and Cd levels were significantly higher (p<0.05) in treated diabetes subjects compared to control subjects, while BMI, glucose and Zn levels were non-significant. Conclusively, the results of this study showed significant alterations in Zn, Se, Cu, Pb and Cd of complicated and uncomplicated diabetes subjects which suggests that increase concentration of toxic metals and reduced trace elements concentration may be a contributing factor to the pathogenesis of diabetes mellitus. |
| format | Article |
| id | doaj-art-2e2802cb7f7744619e6e90e26c39d900 |
| institution | DOAJ |
| issn | 2536-7153 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-2e2802cb7f7744619e6e90e26c39d9002025-08-20T02:51:42ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532024-01-0184405Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti StateOdewusi, O.O., Overah, D.O., Obadire, S.O., Omon, E.A., Sokunbi, Z.T.Alterations in serum levels of trace elements reported in type 2 diabetes mellitus (T2DM) have been linked with induction of T2DM and associated complications. This study was carried out to evaluate the levels of Zinc (Zn), Copper (Cu), Selenium (Se), Lead (Pb) and Cadmium (Cd) in different haptoglobin phenotypes of complicated and uncomplicated diabetic patients. A total of 100 samples comprising of 30 apparently healthy subjects (control), 39 treated and untreated uncomplicated diabetic patients and 31 hypertensive type 2 diabetic patients were recruited for this study. Characterization of serum haptoglobin phenotypes was determined using protein electrophoresis, while Zn, Cu, Se, Pb and Cd were estimated using Atomic Absorption Spectrometry. Results obtained showed that Pb and Cd levels were significantly higher (p<0.05) in treated complicated diabetes subjects compared to control, while glucose, Zn, Se and Cu levels were non-significant (p>0.05). BMI, glucose, Pb and Cd were significantly higher (p<0.05), while Se and Zn were significantly lower (p<0.05) in untreated complicated diabetes subjects compared to control. Cu was non-significantly lower (p>0.05) in untreated complicated diabetes subjects compared to control. The results also showed that Cu, Se, Pb and Cd levels were significantly higher (p<0.05) in treated diabetes subjects compared to control subjects, while BMI, glucose and Zn levels were non-significant. Conclusively, the results of this study showed significant alterations in Zn, Se, Cu, Pb and Cd of complicated and uncomplicated diabetes subjects which suggests that increase concentration of toxic metals and reduced trace elements concentration may be a contributing factor to the pathogenesis of diabetes mellitus.https://sokjmls.com.ng/index.php/SJMLS/article/view/405diabetes mellitus, hypertension, trace element, haptoglobulin, toxic metal. |
| spellingShingle | Odewusi, O.O., Overah, D.O., Obadire, S.O., Omon, E.A., Sokunbi, Z.T. Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State Sokoto Journal of Medical Laboratory Science diabetes mellitus, hypertension, trace element, haptoglobulin, toxic metal. |
| title | Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State |
| title_full | Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State |
| title_fullStr | Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State |
| title_full_unstemmed | Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State |
| title_short | Haptoglobin Characterization and Evaluation of Some Selected Trace Elements and Toxic Metals in Type 2 Diabetes mellitus Patients in Ado-Ekiti, Ekiti State |
| title_sort | haptoglobin characterization and evaluation of some selected trace elements and toxic metals in type 2 diabetes mellitus patients in ado ekiti ekiti state |
| topic | diabetes mellitus, hypertension, trace element, haptoglobulin, toxic metal. |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/405 |
| work_keys_str_mv | AT odewusioooverahdoobadiresoomoneasokunbizt haptoglobincharacterizationandevaluationofsomeselectedtraceelementsandtoxicmetalsintype2diabetesmellituspatientsinadoekitiekitistate |