Immune‐mediated ECM depletion improves tumour perfusion and payload delivery

Immune‐mediated ECM depletion improves tumour perfusion and payload delivery

Abstract High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the immune‐modulating cytokine, tumour necrosi...

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Bibliographic Details
Main Authors: Yen Ling Yeow, Venkata Ramana Kotamraju, Xiao Wang, Meenu Chopra, Nasibah Azme, Jiansha Wu, Tobias D Schoep, Derek S Delaney, Kirk Feindel, Ji Li, Kelsey M Kennedy, Wes M Allen, Brendan F Kennedy, Irma Larma, David D Sampson, Lisa M Mahakian, Brett Z Fite, Hua Zhang, Tomas Friman, Aman P Mann, Farah A Aziz, M Priyanthi Kumarasinghe, Mikael Johansson, Hooi C Ee, George Yeoh, Lingjun Mou, Katherine W Ferrara, Hector Billiran, Ruth Ganss, Erkki Ruoslahti, Juliana Hamzah
Format: Article
Language:English
Published: Springer Nature 2019-11-01
Series:EMBO Molecular Medicine
Subjects:
extracellular matrix
immune cells
peptide
solid tumour
tumour necrosis factor alpha
Online Access:https://doi.org/10.15252/emmm.201910923
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