From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects
The main treatment available for restoration of the corneal endothelium is keratoplasty and DMEK provides faster visual recovery and better postoperative visual acuity when compared to DSAEK. However, the technical challenges related to this technique and the steep technical learning curve seem to p...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/6482095 |
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| _version_ | 1850106481217634304 |
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| author | Raffaele Nuzzi Paola Marolo Federico Tridico |
| author_facet | Raffaele Nuzzi Paola Marolo Federico Tridico |
| author_sort | Raffaele Nuzzi |
| collection | DOAJ |
| description | The main treatment available for restoration of the corneal endothelium is keratoplasty and DMEK provides faster visual recovery and better postoperative visual acuity when compared to DSAEK. However, the technical challenges related to this technique and the steep technical learning curve seem to prevent the overcoming of DSAEK in favor of DMEK. Furthermore, the outcome of lamellar keratoplasty techniques is influenced by problems related to corneal grafting tissue availability, management, and quality. On the other hand, improvements in the field of cell engineering have opened the way for the use of stem cells-derived corneal endothelial cells with regenerative intent. In this overview, latest findings in endothelial cell engineering are reported, and perspectives of clinical application of mesenchymal stem cells for corneal endothelial replacement and regeneration are evaluated. |
| format | Article |
| id | doaj-art-2e1f2676bd0e4ac19c7d7aecb0824541 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-2e1f2676bd0e4ac19c7d7aecb08245412025-08-20T02:38:49ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/64820956482095From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological AspectsRaffaele Nuzzi0Paola Marolo1Federico Tridico2S.C.U. Ophthalmology Unit, “City of Health and Science” University Hospital, Via Cherasco 23, 10126 Turin, ItalyS.C.U. Ophthalmology Unit, “City of Health and Science” University Hospital, Via Cherasco 23, 10126 Turin, ItalyS.C.U. Ophthalmology Unit, “City of Health and Science” University Hospital, Via Cherasco 23, 10126 Turin, ItalyThe main treatment available for restoration of the corneal endothelium is keratoplasty and DMEK provides faster visual recovery and better postoperative visual acuity when compared to DSAEK. However, the technical challenges related to this technique and the steep technical learning curve seem to prevent the overcoming of DSAEK in favor of DMEK. Furthermore, the outcome of lamellar keratoplasty techniques is influenced by problems related to corneal grafting tissue availability, management, and quality. On the other hand, improvements in the field of cell engineering have opened the way for the use of stem cells-derived corneal endothelial cells with regenerative intent. In this overview, latest findings in endothelial cell engineering are reported, and perspectives of clinical application of mesenchymal stem cells for corneal endothelial replacement and regeneration are evaluated.http://dx.doi.org/10.1155/2018/6482095 |
| spellingShingle | Raffaele Nuzzi Paola Marolo Federico Tridico From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects Journal of Ophthalmology |
| title | From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects |
| title_full | From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects |
| title_fullStr | From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects |
| title_full_unstemmed | From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects |
| title_short | From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects |
| title_sort | from dmek to corneal endothelial cell therapy technical and biological aspects |
| url | http://dx.doi.org/10.1155/2018/6482095 |
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