Novel 5-HT6R modulators as mTOR-dependent neuronal autophagy inductors

Novel 5-HT6R modulators as mTOR-dependent neuronal autophagy inductors

Abstract Autophagy is a natural process in which the cell degrades substances through the lysosomal pathway. One of the most studied mechanisms for regulating autophagy is the mTOR signaling pathway. Recent research has shown that the 5-HT6 receptor is linked to the mTOR pathway and can affect cogni...

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Bibliographic Details
Main Authors: José Miguel Alcaíno, Gonzalo Vera, Gonzalo Almarza, Carlos F. Lagos, Claudio A. Terraza, Andrea del Campo, Gonzalo Recabarren-Gajardo
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
5-HT6R
Modulators
mTOR
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-92755-6
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