Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer
Abstract This study aimed to evaluate the ability of serial whole-body dynamic PET/CT to differentiate physiological from abnormal 18F-FDG uptake in the abdomen and pelvis of gynecological cancer patients. We conducted a retrospective study of 61 18F-FDG PET/CT examinations for suspected gynecologic...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-81236-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850216326795100160 |
|---|---|
| author | Sachimi Yamada Tomoya Kotani Nagara Tamaki Yoshitomo Nakai Yasuchiyo Toyama Motoki Nishimura Yasunori Nakamura Takeshi Nii Kei Yamada |
| author_facet | Sachimi Yamada Tomoya Kotani Nagara Tamaki Yoshitomo Nakai Yasuchiyo Toyama Motoki Nishimura Yasunori Nakamura Takeshi Nii Kei Yamada |
| author_sort | Sachimi Yamada |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the ability of serial whole-body dynamic PET/CT to differentiate physiological from abnormal 18F-FDG uptake in the abdomen and pelvis of gynecological cancer patients. We conducted a retrospective study of 61 18F-FDG PET/CT examinations for suspected gynecological malignancies or metastases between March 2018 and January 2020. Our protocol included four-phase dynamic whole-body scans. High-uptake foci with SUVmax > 2.5 in the abdominopelvic region caudal to the renal portal were picked up and visually evaluated as “changed” (disappeared during any phase or morphological changes in more than half of the foci) or “unchanged” in motion on the serial dynamic images. Focal 18F-FDG uptake was observed in 84 foci. Of the 58 foci determined pathologically or clinically to have pathological uptake, no change was observed on serial dynamic imaging in 54 foci (sensitivity, 93%). Of the 26 foci of physiological uptake, temporal changes in uptake were observed in 20 foci using dynamic imaging (specificity, 77%). The positive and negative predictive values were 90% and 83%, respectively, with an accuracy of 88%. Dynamic whole-body 18F-FDG PET/CT imaging allows for differentiation between pathological and physiological uptake in the abdominopelvic region of patients with gynecological cancer. |
| format | Article |
| id | doaj-art-2e16558cdf4c4451aea6e2c7c050e700 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2e16558cdf4c4451aea6e2c7c050e7002025-08-20T02:08:20ZengNature PortfolioScientific Reports2045-23222024-11-011411910.1038/s41598-024-81236-xDynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancerSachimi Yamada0Tomoya Kotani1Nagara Tamaki2Yoshitomo Nakai3Yasuchiyo Toyama4Motoki Nishimura5Yasunori Nakamura6Takeshi Nii7Kei Yamada8Department of Radiology, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineKyoto College of Medical ScienceDepartment of Radiological Technology, University Hospital, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineAbstract This study aimed to evaluate the ability of serial whole-body dynamic PET/CT to differentiate physiological from abnormal 18F-FDG uptake in the abdomen and pelvis of gynecological cancer patients. We conducted a retrospective study of 61 18F-FDG PET/CT examinations for suspected gynecological malignancies or metastases between March 2018 and January 2020. Our protocol included four-phase dynamic whole-body scans. High-uptake foci with SUVmax > 2.5 in the abdominopelvic region caudal to the renal portal were picked up and visually evaluated as “changed” (disappeared during any phase or morphological changes in more than half of the foci) or “unchanged” in motion on the serial dynamic images. Focal 18F-FDG uptake was observed in 84 foci. Of the 58 foci determined pathologically or clinically to have pathological uptake, no change was observed on serial dynamic imaging in 54 foci (sensitivity, 93%). Of the 26 foci of physiological uptake, temporal changes in uptake were observed in 20 foci using dynamic imaging (specificity, 77%). The positive and negative predictive values were 90% and 83%, respectively, with an accuracy of 88%. Dynamic whole-body 18F-FDG PET/CT imaging allows for differentiation between pathological and physiological uptake in the abdominopelvic region of patients with gynecological cancer.https://doi.org/10.1038/s41598-024-81236-xWhole-body PET/CT18F-FDGDynamic acquisitionGynecological cancerPhysiological uptake |
| spellingShingle | Sachimi Yamada Tomoya Kotani Nagara Tamaki Yoshitomo Nakai Yasuchiyo Toyama Motoki Nishimura Yasunori Nakamura Takeshi Nii Kei Yamada Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer Scientific Reports Whole-body PET/CT 18F-FDG Dynamic acquisition Gynecological cancer Physiological uptake |
| title | Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer |
| title_full | Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer |
| title_fullStr | Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer |
| title_full_unstemmed | Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer |
| title_short | Dynamic FDG PET/CT for differentiating focal pelvic uptake in patients with gynecological cancer |
| title_sort | dynamic fdg pet ct for differentiating focal pelvic uptake in patients with gynecological cancer |
| topic | Whole-body PET/CT 18F-FDG Dynamic acquisition Gynecological cancer Physiological uptake |
| url | https://doi.org/10.1038/s41598-024-81236-x |
| work_keys_str_mv | AT sachimiyamada dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT tomoyakotani dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT nagaratamaki dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT yoshitomonakai dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT yasuchiyotoyama dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT motokinishimura dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT yasunorinakamura dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT takeshinii dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer AT keiyamada dynamicfdgpetctfordifferentiatingfocalpelvicuptakeinpatientswithgynecologicalcancer |