Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal
We tested the hypothesis that a high fat meal (HFM) would impair cutaneous vasodilation, while thermotherapy (TT) would reverse the detrimental effects. Eight participants were instrumented with skin heaters and laser-Doppler (LD) probes and tested in three trials: control, HFM, and HFM + TT. Partic...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1902325 |
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| author | Jennifer C. Harvey Bruno T. Roseguini Benjamin M. Goerger Elizabeth A. Fallon Brett J. Wong |
| author_facet | Jennifer C. Harvey Bruno T. Roseguini Benjamin M. Goerger Elizabeth A. Fallon Brett J. Wong |
| author_sort | Jennifer C. Harvey |
| collection | DOAJ |
| description | We tested the hypothesis that a high fat meal (HFM) would impair cutaneous vasodilation, while thermotherapy (TT) would reverse the detrimental effects. Eight participants were instrumented with skin heaters and laser-Doppler (LD) probes and tested in three trials: control, HFM, and HFM + TT. Participants wore a water-perfused suit perfused with 33°C (control and HFM) or 50°C (HFM + TT) water. Participants consumed 1 g fat/kg body weight. Blood samples were taken at baseline and two hours post-HFM. Blood pressure was measured every 5–10 minutes. Microvascular function was assessed via skin local heating from 33°C to 39°C two hours after HFM. Cutaneous vascular conductance (CVC) was calculated and normalized to maximal vasodilation (%CVCmax). HFM had no effect on initial peak (48 ± 4 %CVCmax) compared to control (49 ± 4 %CVCmax) but attenuated the plateau (51 ± 4 %CVCmax) compared to control (63 ± 4 %CVCmax, P < 0.001). Initial peak was augmented in HFM + TT (66 ± 4 %CVCmax) compared to control and HFM (P < 0.05), while plateau (73 ± 3 % CVCmax) was augmented only compared to the HFM trial (P < 0.001). These data suggest that HFM negatively affects cutaneous vasodilation but can be minimized by TT. |
| format | Article |
| id | doaj-art-2e1313587e774299a02de6529c2a7f5a |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2e1313587e774299a02de6529c2a7f5a2025-08-20T03:55:07ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/19023251902325Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat MealJennifer C. Harvey0Bruno T. Roseguini1Benjamin M. Goerger2Elizabeth A. Fallon3Brett J. Wong4Department of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USADepartment of Health & Kinesiology, Purdue University, West Lafayette, IN 47907, USADepartment of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USADepartment of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USADepartment of Kinesiology & Health, Georgia State University, Atlanta, GA 30302-3975, USAWe tested the hypothesis that a high fat meal (HFM) would impair cutaneous vasodilation, while thermotherapy (TT) would reverse the detrimental effects. Eight participants were instrumented with skin heaters and laser-Doppler (LD) probes and tested in three trials: control, HFM, and HFM + TT. Participants wore a water-perfused suit perfused with 33°C (control and HFM) or 50°C (HFM + TT) water. Participants consumed 1 g fat/kg body weight. Blood samples were taken at baseline and two hours post-HFM. Blood pressure was measured every 5–10 minutes. Microvascular function was assessed via skin local heating from 33°C to 39°C two hours after HFM. Cutaneous vascular conductance (CVC) was calculated and normalized to maximal vasodilation (%CVCmax). HFM had no effect on initial peak (48 ± 4 %CVCmax) compared to control (49 ± 4 %CVCmax) but attenuated the plateau (51 ± 4 %CVCmax) compared to control (63 ± 4 %CVCmax, P < 0.001). Initial peak was augmented in HFM + TT (66 ± 4 %CVCmax) compared to control and HFM (P < 0.05), while plateau (73 ± 3 % CVCmax) was augmented only compared to the HFM trial (P < 0.001). These data suggest that HFM negatively affects cutaneous vasodilation but can be minimized by TT.http://dx.doi.org/10.1155/2016/1902325 |
| spellingShingle | Jennifer C. Harvey Bruno T. Roseguini Benjamin M. Goerger Elizabeth A. Fallon Brett J. Wong Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal Journal of Diabetes Research |
| title | Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal |
| title_full | Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal |
| title_fullStr | Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal |
| title_full_unstemmed | Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal |
| title_short | Acute Thermotherapy Prevents Impairments in Cutaneous Microvascular Function Induced by a High Fat Meal |
| title_sort | acute thermotherapy prevents impairments in cutaneous microvascular function induced by a high fat meal |
| url | http://dx.doi.org/10.1155/2016/1902325 |
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