Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context
Summary: Background: Biological age (BA) is considered a better predictor of aging than chronological age (CA). BA acceleration was defined as the disparity between BA and CA. However, there has been inconclusive evidence on whether BA acceleration might be reversed by increased total testosterone...
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Elsevier
2025-04-01
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| author | Weichao Huang Linghui Deng Qiaorui Wen Zilong Zhang Jirong Yue Chichen Zhang Xianghong Zhou Yuming Jin Dan Hu Zhongyuan Jiang Colucci Manuel Robesti Daniele Valdata Aurora Xiaoli Zou Yu Zhan Lei Chen Shaoheng Luo Zuoqiu Sophia Qiang Wei Lu Yang Birong Dong Shengfeng Wang Shi Qiu |
| author_facet | Weichao Huang Linghui Deng Qiaorui Wen Zilong Zhang Jirong Yue Chichen Zhang Xianghong Zhou Yuming Jin Dan Hu Zhongyuan Jiang Colucci Manuel Robesti Daniele Valdata Aurora Xiaoli Zou Yu Zhan Lei Chen Shaoheng Luo Zuoqiu Sophia Qiang Wei Lu Yang Birong Dong Shengfeng Wang Shi Qiu |
| author_sort | Weichao Huang |
| collection | DOAJ |
| description | Summary: Background: Biological age (BA) is considered a better predictor of aging than chronological age (CA). BA acceleration was defined as the disparity between BA and CA. However, there has been inconclusive evidence on whether BA acceleration might be reversed by increased total testosterone (TT). The goal of this cross-sectional study was to investigate the relationship between TT and BA acceleration. Methods: Klemera and Doubal method biological age (KDM-BA) was employed as an indicator of BA in this study. This study involved participants of three ancestries from five cohorts, including the National Health and Nutrition Examination Survey (NHANES, recruited between 1 January 2011 and 31 December 2016), West China Health and Aging Trend (WCHAT, recruited between 1 January 2018 and 31 December 2018), West China Natural Population Cohort Study (WCNPCS, recruited between 1 January 2019 and 31 December 2020), UK Biobank (UKB, recruited between 3 March 2016 and 1 October 2020), and the West China Hospital robot-assisted radical prostatectomy (RARP) cohort (recruited between 1 January 2017 and 31 December 2023). Association between serum TT and BA acceleration were assessed by multivariable linear regression in NHANES, WCHAT, and WCNPCS. Change-to-change analysis was performed to evaluate the association between the dynamic of serum TT and BA acceleration in the UKB. 38 prostate cancer patients underwent adjuvant androgen deprivation therapy (ADT) were included to exploring whether ADT deteriorates BA acceleration. Findings: A total of 6976, 2080, 2133, and 6058 participants from NHANES, WCHAT, WCNPCS, and UKB, respectively, were included in the study. Higher serum TT was consistently associated with attenuated BA acceleration across NHANES, WCHAT, and WCNPCS. In UKB, Box–Cox with negatives allowed (BCN)-transformed relative TT change was significantly associated with decreased BCN-transformed BA acceleration change (β: −0.047, 95% CI: −0.057 to −0.038). The results were remained robust in the stratification analysis, restricted cubic spline regression (RCS), and sensitivity analysis. The pre-and-post ADT paired test further indicated the deprivation of TT accelerated biological aging of prostate cancer patients. Interpretation: This study reveals that higher serum TT was associated with reduced biological aging. Men with increased serum TT on repeat testing demonstrated reduced BA acceleration. Comparison of men with prostate cancer revealed advanced BA acceleration after receiving ADT. This study suggests TT may be a reasonable indicator for biological aging. Funding: National key research and development program of China, Programs from Science and Technology Department of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University. |
| format | Article |
| id | doaj-art-2e0eb2b174d94e8aa39db8488bcc032e |
| institution | DOAJ |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | EClinicalMedicine |
| spelling | doaj-art-2e0eb2b174d94e8aa39db8488bcc032e2025-08-20T03:04:20ZengElsevierEClinicalMedicine2589-53702025-04-018210317810.1016/j.eclinm.2025.103178Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in contextWeichao Huang0Linghui Deng1Qiaorui Wen2Zilong Zhang3Jirong Yue4Chichen Zhang5Xianghong Zhou6Yuming Jin7Dan Hu8Zhongyuan Jiang9Colucci Manuel10Robesti Daniele11Valdata Aurora12Xiaoli Zou13Yu Zhan14Lei Chen15Shaoheng Luo16Zuoqiu Sophia17Qiang Wei18Lu Yang19Birong Dong20Shengfeng Wang21Shi Qiu22Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaNational Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China; Laboratories for Translational Research, Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, SwitzerlandDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaNational Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Clinical Research, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Research, West China Hospital, Sichuan University, Chengdu, ChinaInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500, Bellinzona, Switzerland; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich, CH, SwitzerlandInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500, Bellinzona, Switzerland; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich, CH, SwitzerlandInstitute of Oncology Research (IOR), Oncology Institute of Southern Switzerland (IOSI), CH6500, Bellinzona, Switzerland; Università della Svizzera Italiana, CH6900, Lugano, Switzerland; Department of Health Sciences and Technology (D-HEST) ETH Zurich, Zurich, CH, SwitzerlandDepartment of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaDepartment of Environmental Science and Engineering, Sichuan University, Chengdu, Sichuan, 610065, ChinaDepartment of Clinical Research Management, West China Hospital of Sichuan University, Chengdu, 610041, ChinaInformation Center, West China Hospital, Sichuan University, Chengdu, ChinaPittsburgh Institute, Sichuan University, Chengdu, Sichuan, 610207, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, ChinaDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China; Corresponding author. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu, Sichuan, 610041, China.National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China; Corresponding author. National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu, Sichuan, 610041, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Corresponding author.Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China; Corresponding author. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu, Sichuan, 610041, China.Summary: Background: Biological age (BA) is considered a better predictor of aging than chronological age (CA). BA acceleration was defined as the disparity between BA and CA. However, there has been inconclusive evidence on whether BA acceleration might be reversed by increased total testosterone (TT). The goal of this cross-sectional study was to investigate the relationship between TT and BA acceleration. Methods: Klemera and Doubal method biological age (KDM-BA) was employed as an indicator of BA in this study. This study involved participants of three ancestries from five cohorts, including the National Health and Nutrition Examination Survey (NHANES, recruited between 1 January 2011 and 31 December 2016), West China Health and Aging Trend (WCHAT, recruited between 1 January 2018 and 31 December 2018), West China Natural Population Cohort Study (WCNPCS, recruited between 1 January 2019 and 31 December 2020), UK Biobank (UKB, recruited between 3 March 2016 and 1 October 2020), and the West China Hospital robot-assisted radical prostatectomy (RARP) cohort (recruited between 1 January 2017 and 31 December 2023). Association between serum TT and BA acceleration were assessed by multivariable linear regression in NHANES, WCHAT, and WCNPCS. Change-to-change analysis was performed to evaluate the association between the dynamic of serum TT and BA acceleration in the UKB. 38 prostate cancer patients underwent adjuvant androgen deprivation therapy (ADT) were included to exploring whether ADT deteriorates BA acceleration. Findings: A total of 6976, 2080, 2133, and 6058 participants from NHANES, WCHAT, WCNPCS, and UKB, respectively, were included in the study. Higher serum TT was consistently associated with attenuated BA acceleration across NHANES, WCHAT, and WCNPCS. In UKB, Box–Cox with negatives allowed (BCN)-transformed relative TT change was significantly associated with decreased BCN-transformed BA acceleration change (β: −0.047, 95% CI: −0.057 to −0.038). The results were remained robust in the stratification analysis, restricted cubic spline regression (RCS), and sensitivity analysis. The pre-and-post ADT paired test further indicated the deprivation of TT accelerated biological aging of prostate cancer patients. Interpretation: This study reveals that higher serum TT was associated with reduced biological aging. Men with increased serum TT on repeat testing demonstrated reduced BA acceleration. Comparison of men with prostate cancer revealed advanced BA acceleration after receiving ADT. This study suggests TT may be a reasonable indicator for biological aging. Funding: National key research and development program of China, Programs from Science and Technology Department of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University.http://www.sciencedirect.com/science/article/pii/S2589537025001105Biological agingTestosterone levelsTestosterone deficiencyNHANESUK biobank |
| spellingShingle | Weichao Huang Linghui Deng Qiaorui Wen Zilong Zhang Jirong Yue Chichen Zhang Xianghong Zhou Yuming Jin Dan Hu Zhongyuan Jiang Colucci Manuel Robesti Daniele Valdata Aurora Xiaoli Zou Yu Zhan Lei Chen Shaoheng Luo Zuoqiu Sophia Qiang Wei Lu Yang Birong Dong Shengfeng Wang Shi Qiu Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context EClinicalMedicine Biological aging Testosterone levels Testosterone deficiency NHANES UK biobank |
| title | Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context |
| title_full | Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context |
| title_fullStr | Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context |
| title_full_unstemmed | Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context |
| title_short | Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populationsResearch in context |
| title_sort | dynamics of serum testosterone and biological aging in men insights from chinese american and british populationsresearch in context |
| topic | Biological aging Testosterone levels Testosterone deficiency NHANES UK biobank |
| url | http://www.sciencedirect.com/science/article/pii/S2589537025001105 |
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