The forgotten link: how the oral microbiome shapes childhood growth and development
Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive and physical well-being. Emerging evidence highlights the pivotal role of the oral microbiome—a dynamic microbial ecosystem—in influencing nut...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oral Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1547099/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206701029064704 |
|---|---|
| author | Raymond Rubianto Tjandrawinata Nurlinah Amalia Nurlinah Amalia Nurlinah Amalia Yosi Yohanes Putra Tandi Ariq Fadhil Athallah Caesaroy Afif Wibowo Muhammad Reva Aditya Muhammad Reva Aditya Athaya Rahmanardi Muhammad Athaya Rahmanardi Muhammad Maghfira Rahma Azizah Maghfira Rahma Azizah Farizky Martriano Humardani Ammar Nojaid Jeremy Alvaro Christabel Alfi Agnuristyaningrum Fahrul Nurkolis Fahrul Nurkolis |
| author_facet | Raymond Rubianto Tjandrawinata Nurlinah Amalia Nurlinah Amalia Nurlinah Amalia Yosi Yohanes Putra Tandi Ariq Fadhil Athallah Caesaroy Afif Wibowo Muhammad Reva Aditya Muhammad Reva Aditya Athaya Rahmanardi Muhammad Athaya Rahmanardi Muhammad Maghfira Rahma Azizah Maghfira Rahma Azizah Farizky Martriano Humardani Ammar Nojaid Jeremy Alvaro Christabel Alfi Agnuristyaningrum Fahrul Nurkolis Fahrul Nurkolis |
| author_sort | Raymond Rubianto Tjandrawinata |
| collection | DOAJ |
| description | Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive and physical well-being. Emerging evidence highlights the pivotal role of the oral microbiome—a dynamic microbial ecosystem—in influencing nutritional status, immune response, and overall systemic health. This review explores the intricate interplay between the oral microbiome and stunting, emphasizing mechanisms such as microbial dysbiosis, its impact on nutrient absorption, and immune modulation. Disruptions in the oral microbiome can lead to nutrient malabsorption and systemic inflammation, further exacerbating growth impairments in children. Furthermore, the potential for microbiome-targeted diagnostics and interventions, including probiotics and prebiotics, offers novel strategies to address stunting. A deeper understanding of these interactions may inform innovative diagnostic tools and therapeutic interventions aimed at mitigating stunting through oral microbiome modulation. Integrating oral microbiome research into stunting prevention efforts could provide valuable insights for public health strategies to improve child growth and development, particularly in resource-limited settings. Future research should focus on elucidating the molecular pathways linking the oral microbiome to stunting and developing personalized interventions that optimize microbiome health in early life. |
| format | Article |
| id | doaj-art-2e07c4bf109a49cabd9b3349224a0564 |
| institution | Kabale University |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-2e07c4bf109a49cabd9b3349224a05642025-02-07T06:49:37ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-02-01610.3389/froh.2025.15470991547099The forgotten link: how the oral microbiome shapes childhood growth and developmentRaymond Rubianto Tjandrawinata0Nurlinah Amalia1Nurlinah Amalia2Nurlinah Amalia3Yosi Yohanes Putra Tandi4Ariq Fadhil Athallah5Caesaroy Afif Wibowo6Muhammad Reva Aditya7Muhammad Reva Aditya8Athaya Rahmanardi Muhammad9Athaya Rahmanardi Muhammad10Maghfira Rahma Azizah11Maghfira Rahma Azizah12Farizky Martriano Humardani13Ammar Nojaid14Jeremy Alvaro Christabel15Alfi Agnuristyaningrum16Fahrul Nurkolis17Fahrul Nurkolis18Center for Pharmaceutical and Nutraceutical Research and Policy, Atma Jaya Catholic University of Indonesia, Jakarta, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMaster Program of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Research Center of Indonesia, Surabaya, IndonesiaBachelor of Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMaster Program of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMaster Program of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMaster Program of Biomedical Science, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaDoctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Study Program, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMedical Research Center of Indonesia, Surabaya, IndonesiaMaster of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaChildhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive and physical well-being. Emerging evidence highlights the pivotal role of the oral microbiome—a dynamic microbial ecosystem—in influencing nutritional status, immune response, and overall systemic health. This review explores the intricate interplay between the oral microbiome and stunting, emphasizing mechanisms such as microbial dysbiosis, its impact on nutrient absorption, and immune modulation. Disruptions in the oral microbiome can lead to nutrient malabsorption and systemic inflammation, further exacerbating growth impairments in children. Furthermore, the potential for microbiome-targeted diagnostics and interventions, including probiotics and prebiotics, offers novel strategies to address stunting. A deeper understanding of these interactions may inform innovative diagnostic tools and therapeutic interventions aimed at mitigating stunting through oral microbiome modulation. Integrating oral microbiome research into stunting prevention efforts could provide valuable insights for public health strategies to improve child growth and development, particularly in resource-limited settings. Future research should focus on elucidating the molecular pathways linking the oral microbiome to stunting and developing personalized interventions that optimize microbiome health in early life.https://www.frontiersin.org/articles/10.3389/froh.2025.1547099/fulloral microbiomestuntingchildhood growthdysbiosisprobioticsnutrition |
| spellingShingle | Raymond Rubianto Tjandrawinata Nurlinah Amalia Nurlinah Amalia Nurlinah Amalia Yosi Yohanes Putra Tandi Ariq Fadhil Athallah Caesaroy Afif Wibowo Muhammad Reva Aditya Muhammad Reva Aditya Athaya Rahmanardi Muhammad Athaya Rahmanardi Muhammad Maghfira Rahma Azizah Maghfira Rahma Azizah Farizky Martriano Humardani Ammar Nojaid Jeremy Alvaro Christabel Alfi Agnuristyaningrum Fahrul Nurkolis Fahrul Nurkolis The forgotten link: how the oral microbiome shapes childhood growth and development Frontiers in Oral Health oral microbiome stunting childhood growth dysbiosis probiotics nutrition |
| title | The forgotten link: how the oral microbiome shapes childhood growth and development |
| title_full | The forgotten link: how the oral microbiome shapes childhood growth and development |
| title_fullStr | The forgotten link: how the oral microbiome shapes childhood growth and development |
| title_full_unstemmed | The forgotten link: how the oral microbiome shapes childhood growth and development |
| title_short | The forgotten link: how the oral microbiome shapes childhood growth and development |
| title_sort | forgotten link how the oral microbiome shapes childhood growth and development |
| topic | oral microbiome stunting childhood growth dysbiosis probiotics nutrition |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1547099/full |
| work_keys_str_mv | AT raymondrubiantotjandrawinata theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT nurlinahamalia theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT nurlinahamalia theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT nurlinahamalia theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT yosiyohanesputratandi theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT ariqfadhilathallah theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT caesaroyafifwibowo theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT muhammadrevaaditya theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT muhammadrevaaditya theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT athayarahmanardimuhammad theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT athayarahmanardimuhammad theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT maghfirarahmaazizah theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT maghfirarahmaazizah theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT farizkymartrianohumardani theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT ammarnojaid theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT jeremyalvarochristabel theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT alfiagnuristyaningrum theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT fahrulnurkolis theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT fahrulnurkolis theforgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT raymondrubiantotjandrawinata forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT nurlinahamalia forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT nurlinahamalia forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT nurlinahamalia forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT yosiyohanesputratandi forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT ariqfadhilathallah forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT caesaroyafifwibowo forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT muhammadrevaaditya forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT muhammadrevaaditya forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT athayarahmanardimuhammad forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT athayarahmanardimuhammad forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT maghfirarahmaazizah forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT maghfirarahmaazizah forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT farizkymartrianohumardani forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT ammarnojaid forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT jeremyalvarochristabel forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT alfiagnuristyaningrum forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT fahrulnurkolis forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment AT fahrulnurkolis forgottenlinkhowtheoralmicrobiomeshapeschildhoodgrowthanddevelopment |