Tuberculosis Immunity: Opportunities from Studies with Cattle
Mycobacterium tuberculosis and M. bovis share >99% genetic identity and induce similar host responses and disease profiles upon infection. There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB) including skin-testing pro...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/768542 |
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| author | W. Ray Waters Mitchell V. Palmer Tyler C. Thacker William C. Davis Srinand Sreevatsan Paul Coussens Kieran G. Meade Jayne C. Hope D. Mark Estes |
| author_facet | W. Ray Waters Mitchell V. Palmer Tyler C. Thacker William C. Davis Srinand Sreevatsan Paul Coussens Kieran G. Meade Jayne C. Hope D. Mark Estes |
| author_sort | W. Ray Waters |
| collection | DOAJ |
| description | Mycobacterium tuberculosis and M. bovis share >99% genetic identity and induce similar host responses and disease profiles upon infection. There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB) including skin-testing procedures, M. bovis BCG vaccination, and interferon-γ release assays. The calf TB infection model offers several opportunities to further our understanding of TB immunopathogenesis. Recent observations include correlation of central memory immune responses with TB vaccine efficacy, association of SIRPα+ cells in ESAT-6:CFP10-elicited multinucleate giant cell formation, early γδ T cell responses to TB, antimycobacterial activity of memory CD4+ T cells via granulysin production, association of specific antibody with antigen burden, and suppression of innate immune gene expression in infected animals. Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals. |
| format | Article |
| id | doaj-art-2e0434ece4b94067b48dc09b082af2a5 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2e0434ece4b94067b48dc09b082af2a52025-08-20T03:55:07ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/768542768542Tuberculosis Immunity: Opportunities from Studies with CattleW. Ray Waters0Mitchell V. Palmer1Tyler C. Thacker2William C. Davis3Srinand Sreevatsan4Paul Coussens5Kieran G. Meade6Jayne C. Hope7D. Mark Estes8National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USANational Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USANational Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USADepartment of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USADepartments of Veterinary Population Medicine and Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USAMolecular Biology and Molecular Virology, Department of Animal Science, Michigan State University, East Lansing, MI 48824, USAAnimal Bioscience Centre, Teagasc, Grange, BT55&GE Co. Meath, IrelandLivestock Diseases Programme, Institute for Animal Health, Compton, Near Newbury RG20 7NN, UKDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USAMycobacterium tuberculosis and M. bovis share >99% genetic identity and induce similar host responses and disease profiles upon infection. There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB) including skin-testing procedures, M. bovis BCG vaccination, and interferon-γ release assays. The calf TB infection model offers several opportunities to further our understanding of TB immunopathogenesis. Recent observations include correlation of central memory immune responses with TB vaccine efficacy, association of SIRPα+ cells in ESAT-6:CFP10-elicited multinucleate giant cell formation, early γδ T cell responses to TB, antimycobacterial activity of memory CD4+ T cells via granulysin production, association of specific antibody with antigen burden, and suppression of innate immune gene expression in infected animals. Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals.http://dx.doi.org/10.1155/2011/768542 |
| spellingShingle | W. Ray Waters Mitchell V. Palmer Tyler C. Thacker William C. Davis Srinand Sreevatsan Paul Coussens Kieran G. Meade Jayne C. Hope D. Mark Estes Tuberculosis Immunity: Opportunities from Studies with Cattle Clinical and Developmental Immunology |
| title | Tuberculosis Immunity: Opportunities from Studies with Cattle |
| title_full | Tuberculosis Immunity: Opportunities from Studies with Cattle |
| title_fullStr | Tuberculosis Immunity: Opportunities from Studies with Cattle |
| title_full_unstemmed | Tuberculosis Immunity: Opportunities from Studies with Cattle |
| title_short | Tuberculosis Immunity: Opportunities from Studies with Cattle |
| title_sort | tuberculosis immunity opportunities from studies with cattle |
| url | http://dx.doi.org/10.1155/2011/768542 |
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