Advances and gaps in SARS-CoV-2 infection models.
The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates o...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010161&type=printable |
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| author | César Muñoz-Fontela Lina Widerspick Randy A Albrecht Martin Beer Miles W Carroll Emmie de Wit Michael S Diamond William E Dowling Simon G P Funnell Adolfo García-Sastre Nora M Gerhards Rineke de Jong Vincent J Munster Johan Neyts Stanley Perlman Douglas S Reed Juergen A Richt Ximena Riveros-Balta Chad J Roy Francisco J Salguero Michael Schotsaert Lauren M Schwartz Robert A Seder Joaquim Segalés Seshadri S Vasan Ana María Henao-Restrepo Dan H Barouch |
| author_facet | César Muñoz-Fontela Lina Widerspick Randy A Albrecht Martin Beer Miles W Carroll Emmie de Wit Michael S Diamond William E Dowling Simon G P Funnell Adolfo García-Sastre Nora M Gerhards Rineke de Jong Vincent J Munster Johan Neyts Stanley Perlman Douglas S Reed Juergen A Richt Ximena Riveros-Balta Chad J Roy Francisco J Salguero Michael Schotsaert Lauren M Schwartz Robert A Seder Joaquim Segalés Seshadri S Vasan Ana María Henao-Restrepo Dan H Barouch |
| author_sort | César Muñoz-Fontela |
| collection | DOAJ |
| description | The global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age. |
| format | Article |
| id | doaj-art-2e0188b1403e45f2bd75009acab0b6c7 |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-2e0188b1403e45f2bd75009acab0b6c72025-08-20T03:25:19ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742022-01-01181e101016110.1371/journal.ppat.1010161Advances and gaps in SARS-CoV-2 infection models.César Muñoz-FontelaLina WiderspickRandy A AlbrechtMartin BeerMiles W CarrollEmmie de WitMichael S DiamondWilliam E DowlingSimon G P FunnellAdolfo García-SastreNora M GerhardsRineke de JongVincent J MunsterJohan NeytsStanley PerlmanDouglas S ReedJuergen A RichtXimena Riveros-BaltaChad J RoyFrancisco J SalgueroMichael SchotsaertLauren M SchwartzRobert A SederJoaquim SegalésSeshadri S VasanAna María Henao-RestrepoDan H BarouchThe global response to Coronavirus Disease 2019 (COVID-19) is now facing new challenges such as vaccine inequity and the emergence of SARS-CoV-2 variants of concern (VOCs). Preclinical models of disease, in particular animal models, are essential to investigate VOC pathogenesis, vaccine correlates of protection and postexposure therapies. Here, we provide an update from the World Health Organization (WHO) COVID-19 modeling expert group (WHO-COM) assembled by WHO, regarding advances in preclinical models. In particular, we discuss how animal model research is playing a key role to evaluate VOC virulence, transmission and immune escape, and how animal models are being refined to recapitulate COVID-19 demographic variables such as comorbidities and age.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010161&type=printable |
| spellingShingle | César Muñoz-Fontela Lina Widerspick Randy A Albrecht Martin Beer Miles W Carroll Emmie de Wit Michael S Diamond William E Dowling Simon G P Funnell Adolfo García-Sastre Nora M Gerhards Rineke de Jong Vincent J Munster Johan Neyts Stanley Perlman Douglas S Reed Juergen A Richt Ximena Riveros-Balta Chad J Roy Francisco J Salguero Michael Schotsaert Lauren M Schwartz Robert A Seder Joaquim Segalés Seshadri S Vasan Ana María Henao-Restrepo Dan H Barouch Advances and gaps in SARS-CoV-2 infection models. PLoS Pathogens |
| title | Advances and gaps in SARS-CoV-2 infection models. |
| title_full | Advances and gaps in SARS-CoV-2 infection models. |
| title_fullStr | Advances and gaps in SARS-CoV-2 infection models. |
| title_full_unstemmed | Advances and gaps in SARS-CoV-2 infection models. |
| title_short | Advances and gaps in SARS-CoV-2 infection models. |
| title_sort | advances and gaps in sars cov 2 infection models |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010161&type=printable |
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