Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats.
Monosodium glutamate (MSG) is the sodium salt of glutamic acid, it’s noxious to human and experimental animals. Nowadays, Zinc oxide nanoparticles (ZnO-NPs) are among the most widely used metal oxide nanoparticles in biological applications because of their cost-effectiveness and superior...
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College of Education for Pure Sciences
2025-01-01
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| Series: | مجلة التربية والعلم |
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| Online Access: | https://edusj.uomosul.edu.iq/article_184942_0d491bfa5161467c97fd3a2ac07cf4f1.pdf |
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| author | Azheen Abdulrahman Shang Abdulqadir Inaam Mustafa |
| author_facet | Azheen Abdulrahman Shang Abdulqadir Inaam Mustafa |
| author_sort | Azheen Abdulrahman |
| collection | DOAJ |
| description | Monosodium glutamate (MSG) is the sodium salt of glutamic acid, it’s noxious to human and experimental animals. Nowadays, Zinc oxide nanoparticles (ZnO-NPs) are among the most widely used metal oxide nanoparticles in biological applications because of their cost-effectiveness and superior biocompatibility. Current research aims to assess ZnO-NPs protective effect against MSG-induced hepatotoxicity and nephrotoxicity in rats. In the present investigation, 16 female mature rats were randomly distributed over four groups. The rats of the first group were daily received 1 ml normal saline intraperitoneally, the rats of second group were administrated with 4 mg/kg MSG by gavage, the rats of third group were administrated with 10 mg/kg ZnO-NPs intraperitoneally, and the rats of fourth group were administrated with the mixture of the MSG/ZnO-NPs. After 14 days, all rats were weighed; then, the liver and kidneys were processed using histopathological techniques, and blood specimens were used for biochemical analysis. MSG generated various histological changes in liver tissues, including hepatocyte deterioration, inflammation, and vascular congestion.Regarding the kidney, certain histological alterations, such as a contracted glomerulus, inflammatory infiltration, congestion, and tubule dilatation following MSG treatment, were detected. Regarding biochemical parameters, MSG elevated each AST, ALT, ALP, urea, and MDA level. More importantly, ZnO-NPs could decrease the negative influences of histological and biochemical changes that MSG causes in both the liver and kidney of rats. ZnO-NP therapy improved the aberrant histological changes in the liver and kidneys caused by MSG. |
| format | Article |
| id | doaj-art-2e0159fc60cc45ff93fdcedf3b24e446 |
| institution | DOAJ |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| publishDate | 2025-01-01 |
| publisher | College of Education for Pure Sciences |
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| series | مجلة التربية والعلم |
| spelling | doaj-art-2e0159fc60cc45ff93fdcedf3b24e4462025-08-20T02:40:10ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302025-01-01341455610.33899/edusj.2024.153182.1497184942Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats.Azheen Abdulrahman0Shang Abdulqadir1Inaam Mustafa2Department of Biology, College of Science, Salahaddin University-Erbil, Erbil Kurdistan Region, IraqDepartment of Biology, College of Science, Salahaddin University-Erbil, Erbil Kurdistan Region, Iraq.Department of Biology, College of Science, Salahaddin University-Erbil, Erbil Kurdistan Region, Iraq.Monosodium glutamate (MSG) is the sodium salt of glutamic acid, it’s noxious to human and experimental animals. Nowadays, Zinc oxide nanoparticles (ZnO-NPs) are among the most widely used metal oxide nanoparticles in biological applications because of their cost-effectiveness and superior biocompatibility. Current research aims to assess ZnO-NPs protective effect against MSG-induced hepatotoxicity and nephrotoxicity in rats. In the present investigation, 16 female mature rats were randomly distributed over four groups. The rats of the first group were daily received 1 ml normal saline intraperitoneally, the rats of second group were administrated with 4 mg/kg MSG by gavage, the rats of third group were administrated with 10 mg/kg ZnO-NPs intraperitoneally, and the rats of fourth group were administrated with the mixture of the MSG/ZnO-NPs. After 14 days, all rats were weighed; then, the liver and kidneys were processed using histopathological techniques, and blood specimens were used for biochemical analysis. MSG generated various histological changes in liver tissues, including hepatocyte deterioration, inflammation, and vascular congestion.Regarding the kidney, certain histological alterations, such as a contracted glomerulus, inflammatory infiltration, congestion, and tubule dilatation following MSG treatment, were detected. Regarding biochemical parameters, MSG elevated each AST, ALT, ALP, urea, and MDA level. More importantly, ZnO-NPs could decrease the negative influences of histological and biochemical changes that MSG causes in both the liver and kidney of rats. ZnO-NP therapy improved the aberrant histological changes in the liver and kidneys caused by MSG.https://edusj.uomosul.edu.iq/article_184942_0d491bfa5161467c97fd3a2ac07cf4f1.pdfmsghepatotoxicitynephrotoxicityzno-nps |
| spellingShingle | Azheen Abdulrahman Shang Abdulqadir Inaam Mustafa Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats. مجلة التربية والعلم msg hepatotoxicity nephrotoxicity zno-nps |
| title | Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats. |
| title_full | Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats. |
| title_fullStr | Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats. |
| title_full_unstemmed | Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats. |
| title_short | Protective Roles of Green Extract Zinc Oxide Nanoparticles on Monosodium Glutamate-Induced Hepatotoxicity and Nephrotoxicity in Female Rats. |
| title_sort | protective roles of green extract zinc oxide nanoparticles on monosodium glutamate induced hepatotoxicity and nephrotoxicity in female rats |
| topic | msg hepatotoxicity nephrotoxicity zno-nps |
| url | https://edusj.uomosul.edu.iq/article_184942_0d491bfa5161467c97fd3a2ac07cf4f1.pdf |
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