Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population
Diabetes mellitus (DM) and also anemia are common in the elderly and have a negative impact on the clinical outcomes of patients. The coexistence of anemia and DM seems to be insufficiently recognized; therefore, the aim of our study is to analyze the incidence and clinical consequences of this coex...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8745968 |
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| author | S. S. Michalak E. Wolny-Rokicka E. Nowakowska M. Michalak L. Gil |
| author_facet | S. S. Michalak E. Wolny-Rokicka E. Nowakowska M. Michalak L. Gil |
| author_sort | S. S. Michalak |
| collection | DOAJ |
| description | Diabetes mellitus (DM) and also anemia are common in the elderly and have a negative impact on the clinical outcomes of patients. The coexistence of anemia and DM seems to be insufficiently recognized; therefore, the aim of our study is to analyze the incidence and clinical consequences of this coexistence, including mortality, in the population of people aged ≥60. A retrospective study was conducted on 981 primary care clinic patients aged ≥60 during 2013-2014. The prevalence of coexistence of DM and anemia (defined in accordance with WHO) and data on the incidence of comorbidities, hospitalization, medical procedures, and all-cause mortality were analyzed. In the study population, 25% had DM, while 5.4% had both DM and anemia. Peripheral artery disease (PAD) was found in 48 patients (4.89%) of the entire study population, more often in men (p<0.001). Diabetic patients with anemia compared to nonanemic diabetics had more comorbidities (median 4 (4, 5) vs. 3 (2–4); p<0.001)—PAD more often (p=0.004), more hospitalization (median 2 (0–11) vs. 0 (0–11); p<0.001), and more frequent medical procedures (e.g., percutaneous coronary intervention (p<0.001), coronary artery bypass surgery (p=0.027), arteriography (p<0.001), and bypass surgery or endovascular treatments of lower limb ischemia (p<0.001)). The cumulative survival of patients with both DM and anemia vs. nonanemic diabetics at 36 months was 86.4% vs. 99.3% (p<0.001). A multivariate logistic regression model showed anemia to be a significant risk factor for death in diabetic patients (p=0.013). Patients with both DM and anemia have more comorbidities than nonanemic diabetic patients; they are more often hospitalized, require medical procedures more frequently, and are at a higher risk of death. Effective treatment of anemia in patients with DM is advisable and may well improve the prognosis of patients. |
| format | Article |
| id | doaj-art-2e010aad8d08460e9673c15a79fe9527 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2e010aad8d08460e9673c15a79fe95272025-08-20T02:38:49ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/87459688745968Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly PopulationS. S. Michalak0E. Wolny-Rokicka1E. Nowakowska2M. Michalak3L. Gil4Department of Pharmacology and Toxicology, Collegium Medicum, University of Zielona Gora, Zielona Gora, PolandDepartment of Radiotherapy, Multidisciplinary Hospital, Gorzow Wielkopolski, PolandDepartment of Pharmacology and Toxicology, Collegium Medicum, University of Zielona Gora, Zielona Gora, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, PolandDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, PolandDiabetes mellitus (DM) and also anemia are common in the elderly and have a negative impact on the clinical outcomes of patients. The coexistence of anemia and DM seems to be insufficiently recognized; therefore, the aim of our study is to analyze the incidence and clinical consequences of this coexistence, including mortality, in the population of people aged ≥60. A retrospective study was conducted on 981 primary care clinic patients aged ≥60 during 2013-2014. The prevalence of coexistence of DM and anemia (defined in accordance with WHO) and data on the incidence of comorbidities, hospitalization, medical procedures, and all-cause mortality were analyzed. In the study population, 25% had DM, while 5.4% had both DM and anemia. Peripheral artery disease (PAD) was found in 48 patients (4.89%) of the entire study population, more often in men (p<0.001). Diabetic patients with anemia compared to nonanemic diabetics had more comorbidities (median 4 (4, 5) vs. 3 (2–4); p<0.001)—PAD more often (p=0.004), more hospitalization (median 2 (0–11) vs. 0 (0–11); p<0.001), and more frequent medical procedures (e.g., percutaneous coronary intervention (p<0.001), coronary artery bypass surgery (p=0.027), arteriography (p<0.001), and bypass surgery or endovascular treatments of lower limb ischemia (p<0.001)). The cumulative survival of patients with both DM and anemia vs. nonanemic diabetics at 36 months was 86.4% vs. 99.3% (p<0.001). A multivariate logistic regression model showed anemia to be a significant risk factor for death in diabetic patients (p=0.013). Patients with both DM and anemia have more comorbidities than nonanemic diabetic patients; they are more often hospitalized, require medical procedures more frequently, and are at a higher risk of death. Effective treatment of anemia in patients with DM is advisable and may well improve the prognosis of patients.http://dx.doi.org/10.1155/2021/8745968 |
| spellingShingle | S. S. Michalak E. Wolny-Rokicka E. Nowakowska M. Michalak L. Gil Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population Journal of Diabetes Research |
| title | Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population |
| title_full | Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population |
| title_fullStr | Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population |
| title_full_unstemmed | Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population |
| title_short | Clinical Implications of the Coexistence of Anemia and Diabetes Mellitus in the Elderly Population |
| title_sort | clinical implications of the coexistence of anemia and diabetes mellitus in the elderly population |
| url | http://dx.doi.org/10.1155/2021/8745968 |
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