Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases
Acute inflammatory responses are host-protective and normally self-limited; these responses can maintain cell homeostasis and promote defense against various infections and damage factors. However, when improperly managed or inappropriately activated, acute inflammation can lead to persistent and un...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/2380319 |
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| _version_ | 1849693398026420224 |
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| author | Shi Tang Ming Wan Wei Huang R. C. Stanton Yong Xu |
| author_facet | Shi Tang Ming Wan Wei Huang R. C. Stanton Yong Xu |
| author_sort | Shi Tang |
| collection | DOAJ |
| description | Acute inflammatory responses are host-protective and normally self-limited; these responses can maintain cell homeostasis and promote defense against various infections and damage factors. However, when improperly managed or inappropriately activated, acute inflammation can lead to persistent and uncontrolled chronic inflammation, which is associated with many other chronic diseases including cardiovascular disease and metabolic disease. Recently, studies have shown that resolution of acute inflammation is a biosynthetically active process. Specialized proresolving lipid mediators (SPMs) known as resolvins and protectins are autacoids that resolve inflammation. A new family of anti-inflammatory and proresolving lipid mediators have recently been reported, known as maresins, which are biosynthesized from docosahexaenoic acid (DHA) by macrophages, have a conjugated double-bond system, and display strong anti-inflammatory and proresolving activity. Here, we review the biological actions, pathways, and mechanisms of maresins, which may play pivotal roles in the resolution of inflammation. |
| format | Article |
| id | doaj-art-2dfa62e665b54008ada2fdc9a4e7b3a0 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2dfa62e665b54008ada2fdc9a4e7b3a02025-08-20T03:20:26ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/23803192380319Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related DiseasesShi Tang0Ming Wan1Wei Huang2R. C. Stanton3Yong Xu4Endocrinology Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaEndocrinology Department, The Affiliated Hospital of Nuclear Industry 416 Hospital, Chengdu, Sichuan 610000, ChinaEndocrinology Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaJoslin Diabetes Center, Boston, MA, USAEndocrinology Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaAcute inflammatory responses are host-protective and normally self-limited; these responses can maintain cell homeostasis and promote defense against various infections and damage factors. However, when improperly managed or inappropriately activated, acute inflammation can lead to persistent and uncontrolled chronic inflammation, which is associated with many other chronic diseases including cardiovascular disease and metabolic disease. Recently, studies have shown that resolution of acute inflammation is a biosynthetically active process. Specialized proresolving lipid mediators (SPMs) known as resolvins and protectins are autacoids that resolve inflammation. A new family of anti-inflammatory and proresolving lipid mediators have recently been reported, known as maresins, which are biosynthesized from docosahexaenoic acid (DHA) by macrophages, have a conjugated double-bond system, and display strong anti-inflammatory and proresolving activity. Here, we review the biological actions, pathways, and mechanisms of maresins, which may play pivotal roles in the resolution of inflammation.http://dx.doi.org/10.1155/2018/2380319 |
| spellingShingle | Shi Tang Ming Wan Wei Huang R. C. Stanton Yong Xu Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases Mediators of Inflammation |
| title | Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases |
| title_full | Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases |
| title_fullStr | Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases |
| title_full_unstemmed | Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases |
| title_short | Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases |
| title_sort | maresins specialized proresolving lipid mediators and their potential role in inflammatory related diseases |
| url | http://dx.doi.org/10.1155/2018/2380319 |
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