Liquid biopsy using plasma proteomics in predicting efficacy and tolerance of PD-1/PD-L1 blockades in NSCLC: a prospective exploratory study

Liquid biopsy using plasma proteomics in predicting efficacy and tolerance of PD-1/PD-L1 blockades in NSCLC: a prospective exploratory study

Abstract Immune checkpoint inhibitors (ICIs) show limited efficacy in non-small cell lung cancer (NSCLC), highlighting the need for predictive biomarkers. Here we prospectively analysed serial plasma samples from 34 ICI-treated advanced NSCLC patients (plus 30 validation samples) using the Olink Imm...

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Bibliographic Details
Main Authors: Yuan Gao, Fei Qi, Wenhao Zhou, Peng Jiang, Mingming Hu, Ying Wang, Congcong Song, Yi Han, Dongdong Li, Na Qin, Hongmei Zhang, Haitao Luo, Tongmei Zhang, Hongxia Li
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Molecular Biomedicine
Subjects:
Non-small cell lung cancer
Immune checkpoint inhibitor
Plasma proteomics
Efficacy
Risk score
Online Access:https://doi.org/10.1186/s43556-025-00291-6
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