Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter
Abstract Photothermal therapy (PTT) represents a promising advance in oncological treatments, utilizing light-induced heat mediated by photothermal agents to target and destroy cancer cells with high precision. Despite its potential, the clinical application of PTT is often limited by the efficiency...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Nano |
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| Online Access: | https://doi.org/10.1186/s11671-025-04289-5 |
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| author | Ming-Chung Wu Yin-Hsuan Chang Ting-Han Lin Chun-Yuan Wu Jia-Mao Chang Yu-Jen Lu |
| author_facet | Ming-Chung Wu Yin-Hsuan Chang Ting-Han Lin Chun-Yuan Wu Jia-Mao Chang Yu-Jen Lu |
| author_sort | Ming-Chung Wu |
| collection | DOAJ |
| description | Abstract Photothermal therapy (PTT) represents a promising advance in oncological treatments, utilizing light-induced heat mediated by photothermal agents to target and destroy cancer cells with high precision. Despite its potential, the clinical application of PTT is often limited by the efficiency of photothermal agents and their biocompatibility, highlighting a crucial need for novel materials that can safely and effectively convert light into therapeutic heat. This study demonstrates the two-dimensional Bi2Se3 nanosheets with tailored nanostructure via a solvothermal process. This study controls over their structural and photothermal properties by accurately optimizing synthesis conditions. In situ experiments provide insights into the crystallographic and phonon characteristics at varying temperatures, underscoring the thermal stability of Bi2Se3 nanosheets. Notably, these nanosheets demonstrate a high photothermal conversion efficiency, rapidly raising the tumor site temperature to 53.1 °C within 180 s, resulting in rapid tumor cell ablation. Significant tumor growth suppression is also observed, with the median survival of mice treated with the particle and light combination extending to 34 days. These findings confirm the stable in vivo thermal properties of Bi2Se3 nanosheets, establishing them as a potent candidate for future photothermal therapy applications. |
| format | Article |
| id | doaj-art-2df2b56850d441a8a1c79d5e87df72b8 |
| institution | Kabale University |
| issn | 2731-9229 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Nano |
| spelling | doaj-art-2df2b56850d441a8a1c79d5e87df72b82025-08-20T03:46:16ZengSpringerDiscover Nano2731-92292025-07-0120111310.1186/s11671-025-04289-5Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converterMing-Chung Wu0Yin-Hsuan Chang1Ting-Han Lin2Chun-Yuan Wu3Jia-Mao Chang4Yu-Jen Lu5Department of Chemical and Materials Engineering, College of Engineering, Chang Gung UniversityDepartment of Chemical and Materials Engineering, College of Engineering, Chang Gung UniversityDepartment of Chemical and Materials Engineering, College of Engineering, Chang Gung UniversityCollege of Medicine, Chang Gung UniversityDepartment of Chemical and Materials Engineering, College of Engineering, Chang Gung UniversityCollege of Medicine, Chang Gung UniversityAbstract Photothermal therapy (PTT) represents a promising advance in oncological treatments, utilizing light-induced heat mediated by photothermal agents to target and destroy cancer cells with high precision. Despite its potential, the clinical application of PTT is often limited by the efficiency of photothermal agents and their biocompatibility, highlighting a crucial need for novel materials that can safely and effectively convert light into therapeutic heat. This study demonstrates the two-dimensional Bi2Se3 nanosheets with tailored nanostructure via a solvothermal process. This study controls over their structural and photothermal properties by accurately optimizing synthesis conditions. In situ experiments provide insights into the crystallographic and phonon characteristics at varying temperatures, underscoring the thermal stability of Bi2Se3 nanosheets. Notably, these nanosheets demonstrate a high photothermal conversion efficiency, rapidly raising the tumor site temperature to 53.1 °C within 180 s, resulting in rapid tumor cell ablation. Significant tumor growth suppression is also observed, with the median survival of mice treated with the particle and light combination extending to 34 days. These findings confirm the stable in vivo thermal properties of Bi2Se3 nanosheets, establishing them as a potent candidate for future photothermal therapy applications.https://doi.org/10.1186/s11671-025-04289-5Photothermal therapy (PTT)Bi2Se3 nanosheetsSolvothermal synthesisPhotothermal conversion efficiencyThermal stability |
| spellingShingle | Ming-Chung Wu Yin-Hsuan Chang Ting-Han Lin Chun-Yuan Wu Jia-Mao Chang Yu-Jen Lu Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter Discover Nano Photothermal therapy (PTT) Bi2Se3 nanosheets Solvothermal synthesis Photothermal conversion efficiency Thermal stability |
| title | Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter |
| title_full | Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter |
| title_fullStr | Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter |
| title_full_unstemmed | Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter |
| title_short | Enhanced photothermal therapy for tumor ablation: structural and functional insights into Bi2Se3 nanosheets as Light-to-Heat converter |
| title_sort | enhanced photothermal therapy for tumor ablation structural and functional insights into bi2se3 nanosheets as light to heat converter |
| topic | Photothermal therapy (PTT) Bi2Se3 nanosheets Solvothermal synthesis Photothermal conversion efficiency Thermal stability |
| url | https://doi.org/10.1186/s11671-025-04289-5 |
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