Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines

Photoredox-catalyzed phosphonylation of bromo-substituted 1,10-phenanthrolines under visible light irradiation was studied. The reaction was shown to proceed under mild conditions with Eosin Y as a photocatalyst in DMSO under blue light irradiation. It is transition-metal-free and affords the target...

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Main Authors: Gleb V. Morozkov, Artem A. Troickiy, Alexei D. Averin, Alexander Yu. Mitrofanov, Anton S. Abel, Irina P. Beletskaya
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/29/23/5558
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author Gleb V. Morozkov
Artem A. Troickiy
Alexei D. Averin
Alexander Yu. Mitrofanov
Anton S. Abel
Irina P. Beletskaya
author_facet Gleb V. Morozkov
Artem A. Troickiy
Alexei D. Averin
Alexander Yu. Mitrofanov
Anton S. Abel
Irina P. Beletskaya
author_sort Gleb V. Morozkov
collection DOAJ
description Photoredox-catalyzed phosphonylation of bromo-substituted 1,10-phenanthrolines under visible light irradiation was studied. The reaction was shown to proceed under mild conditions with Eosin Y as a photocatalyst in DMSO under blue light irradiation. It is transition-metal-free and affords the target phosphonate-substituted 1,10-phenanthrolines in moderate yields (26–51%) in 22 to 40 h. The rate and selectivity of the reaction depend largely on the position of the bromine atom, as well as on the nature and position of other substituents in the 1,10-phenanthroline core.
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publisher MDPI AG
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spelling doaj-art-2deb8cc472214f24a2649962fa04eb7f2025-08-20T02:38:45ZengMDPI AGMolecules1420-30492024-11-012923555810.3390/molecules29235558Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-PhenanthrolinesGleb V. Morozkov0Artem A. Troickiy1Alexei D. Averin2Alexander Yu. Mitrofanov3Anton S. Abel4Irina P. Beletskaya5Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, RussiaDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, RussiaPhotoredox-catalyzed phosphonylation of bromo-substituted 1,10-phenanthrolines under visible light irradiation was studied. The reaction was shown to proceed under mild conditions with Eosin Y as a photocatalyst in DMSO under blue light irradiation. It is transition-metal-free and affords the target phosphonate-substituted 1,10-phenanthrolines in moderate yields (26–51%) in 22 to 40 h. The rate and selectivity of the reaction depend largely on the position of the bromine atom, as well as on the nature and position of other substituents in the 1,10-phenanthroline core.https://www.mdpi.com/1420-3049/29/23/5558phosphonylation1,10-phenanthrolinephotocatalysisorganic photocatalyststriethyl phosphite
spellingShingle Gleb V. Morozkov
Artem A. Troickiy
Alexei D. Averin
Alexander Yu. Mitrofanov
Anton S. Abel
Irina P. Beletskaya
Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines
Molecules
phosphonylation
1,10-phenanthroline
photocatalysis
organic photocatalysts
triethyl phosphite
title Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines
title_full Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines
title_fullStr Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines
title_full_unstemmed Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines
title_short Visible Light Photoredox Catalysis in the Synthesis of Phosphonate-Substituted 1,10-Phenanthrolines
title_sort visible light photoredox catalysis in the synthesis of phosphonate substituted 1 10 phenanthrolines
topic phosphonylation
1,10-phenanthroline
photocatalysis
organic photocatalysts
triethyl phosphite
url https://www.mdpi.com/1420-3049/29/23/5558
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