The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.

<h4>Background</h4>People with severe mental illness (SMI) are more likely to develop long-term physical health conditions, including type 2 diabetes and cardiovascular disease, compared to people without SMI. This contributes to an inequality in life expectancy known as the 'mortal...

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Main Authors: Claire Carswell, Kate Bramham, Joseph Chilcot, Rowena Jacobs, David Osborn, Najma Siddiqi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0310568
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author Claire Carswell
Kate Bramham
Joseph Chilcot
Rowena Jacobs
David Osborn
Najma Siddiqi
author_facet Claire Carswell
Kate Bramham
Joseph Chilcot
Rowena Jacobs
David Osborn
Najma Siddiqi
author_sort Claire Carswell
collection DOAJ
description <h4>Background</h4>People with severe mental illness (SMI) are more likely to develop long-term physical health conditions, including type 2 diabetes and cardiovascular disease, compared to people without SMI. This contributes to an inequality in life expectancy known as the 'mortality gap'. Chronic kidney disease (CKD) is a growing global health concern set to be the 5th leading cause of life-years lost by 2040. However, there is limited research exploring the relationship between CKD and SMI. This systematic review will aim to examine the prevalence and incidence of CKD among people with SMI.<h4>Methods</h4>We will search Medline, Embase, PsycINFO, CINAHL, Scopus and Web of Science for primary epidemiological research reporting the prevalence or incidence of CKD among people with SMI in any setting. Retrieved records will be managed in Covidence and screened by two independent reviewers. Data will be extracted from included studies using a piloted data extraction form, and the quality of studies will be evaluated using the appropriate JBI Critical Appraisal Checklist. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. Data from the included studies will be narratively synthesised. Meta-analyses will be conducted using random effects models to examine the prevalence and incidence of CKD among people with SMI.<h4>Discussion</h4>There is limited research exploring the relationship between CKD and SMI, and this proposed systematic review will be the first to examine the prevalence of CKD among people with SMI. This review will highlight the extent of the problem and provide a foundation for future research to improve health outcomes for people with SMI.
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spelling doaj-art-2de2876299774ea8ba36995e0879bc1b2025-02-07T05:30:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031056810.1371/journal.pone.0310568The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.Claire CarswellKate BramhamJoseph ChilcotRowena JacobsDavid OsbornNajma Siddiqi<h4>Background</h4>People with severe mental illness (SMI) are more likely to develop long-term physical health conditions, including type 2 diabetes and cardiovascular disease, compared to people without SMI. This contributes to an inequality in life expectancy known as the 'mortality gap'. Chronic kidney disease (CKD) is a growing global health concern set to be the 5th leading cause of life-years lost by 2040. However, there is limited research exploring the relationship between CKD and SMI. This systematic review will aim to examine the prevalence and incidence of CKD among people with SMI.<h4>Methods</h4>We will search Medline, Embase, PsycINFO, CINAHL, Scopus and Web of Science for primary epidemiological research reporting the prevalence or incidence of CKD among people with SMI in any setting. Retrieved records will be managed in Covidence and screened by two independent reviewers. Data will be extracted from included studies using a piloted data extraction form, and the quality of studies will be evaluated using the appropriate JBI Critical Appraisal Checklist. The certainty of evidence will be assessed using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. Data from the included studies will be narratively synthesised. Meta-analyses will be conducted using random effects models to examine the prevalence and incidence of CKD among people with SMI.<h4>Discussion</h4>There is limited research exploring the relationship between CKD and SMI, and this proposed systematic review will be the first to examine the prevalence of CKD among people with SMI. This review will highlight the extent of the problem and provide a foundation for future research to improve health outcomes for people with SMI.https://doi.org/10.1371/journal.pone.0310568
spellingShingle Claire Carswell
Kate Bramham
Joseph Chilcot
Rowena Jacobs
David Osborn
Najma Siddiqi
The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.
PLoS ONE
title The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.
title_full The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.
title_fullStr The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.
title_full_unstemmed The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.
title_short The prevalence of chronic kidney disease in people with severe mental illness: A systematic review protocol.
title_sort prevalence of chronic kidney disease in people with severe mental illness a systematic review protocol
url https://doi.org/10.1371/journal.pone.0310568
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