Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain
Low back pain (LBP) has long been the leading cause of worldwide productivity loss and the top cause of years lived with disability. Observational studies have reported associations between brain imaging-derived phenotypes (IDPs) and LBP; however, it is uncertain whether these relationships are caus...
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Elsevier
2025-09-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002527 |
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| author | Xiao-Yan Xie Jian-Wei Lin Jia-Yu Fang Zhuo-Chen Chen Peng-Cheng Li Xiao-Yan Huang Ming-Yan Guo Li-Ling Lin Ming-Hui Cao |
| author_facet | Xiao-Yan Xie Jian-Wei Lin Jia-Yu Fang Zhuo-Chen Chen Peng-Cheng Li Xiao-Yan Huang Ming-Yan Guo Li-Ling Lin Ming-Hui Cao |
| author_sort | Xiao-Yan Xie |
| collection | DOAJ |
| description | Low back pain (LBP) has long been the leading cause of worldwide productivity loss and the top cause of years lived with disability. Observational studies have reported associations between brain imaging-derived phenotypes (IDPs) and LBP; however, it is uncertain whether these relationships are causal. Bidirectional two-sample Mendelian randomization (MR) analyses were applied to explore the causal relationship between IDPs and LBP. Summary data of 587 brain IDPs (N = 33,224 individuals) from the UK Biobank and LBP (13,178 cases and 164,682 controls) from the FinnGen database were obtained respectively. Inverse variance weighted (IVW) was used as the primary MR analysis method. The MR Egger, Weighted median, Simple mode, Weighted mode, MR-RAPS, BWMR were supplemented. Sensitivity analyses were applied to demonstrate the reliability of the results. 45 IDPs were identified for which there was evidence of a causal impact on the risk of LBP in total. Forward MR identified 12 IDPs associated with a higher risk of LBP (odds ratio, OR range from 1.06 to 1.93, P ＜0.05) and 19 IDPs associated with a lower risk of LBP (OR range from 0.61 to 0.92, P ＜0.05). Reverse MR showed that genetically predicted LBP was positively correlated with 6 IDPs (β range from 0.10 to 0.17, P ＜0.05) and negatively correlated with 8 IDPs (β range from −0.15 to −0.10, P ＜0.05). There is a relationship between IDPs and LBP risk. Our findings provide potential strategies for predicting LBP risk at the brain-imaging level. |
| format | Article |
| id | doaj-art-2ddfd7114f5a4ae8b226c5aa34ceb4f9 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-2ddfd7114f5a4ae8b226c5aa34ceb4f92025-08-20T03:42:14ZengElsevierBrain Research Bulletin1873-27472025-09-0122911144010.1016/j.brainresbull.2025.111440Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back painXiao-Yan Xie0Jian-Wei Lin1Jia-Yu Fang2Zhuo-Chen Chen3Peng-Cheng Li4Xiao-Yan Huang5Ming-Yan Guo6Li-Ling Lin7Ming-Hui Cao8Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei 516621, ChinaBig Data Laboratory, Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, ChinaDepartment of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Anesthesiology, Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou 510120, ChinaDepartment of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei 516621, ChinaDepartment of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Correspondence to: Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yan Jiang West Road, Guangzhou 510120, China.Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei 516621, China; Correspondence to: Department of Anesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yan Jiang West Road, Guangzhou 510120, China.Low back pain (LBP) has long been the leading cause of worldwide productivity loss and the top cause of years lived with disability. Observational studies have reported associations between brain imaging-derived phenotypes (IDPs) and LBP; however, it is uncertain whether these relationships are causal. Bidirectional two-sample Mendelian randomization (MR) analyses were applied to explore the causal relationship between IDPs and LBP. Summary data of 587 brain IDPs (N = 33,224 individuals) from the UK Biobank and LBP (13,178 cases and 164,682 controls) from the FinnGen database were obtained respectively. Inverse variance weighted (IVW) was used as the primary MR analysis method. The MR Egger, Weighted median, Simple mode, Weighted mode, MR-RAPS, BWMR were supplemented. Sensitivity analyses were applied to demonstrate the reliability of the results. 45 IDPs were identified for which there was evidence of a causal impact on the risk of LBP in total. Forward MR identified 12 IDPs associated with a higher risk of LBP (odds ratio, OR range from 1.06 to 1.93, P ＜0.05) and 19 IDPs associated with a lower risk of LBP (OR range from 0.61 to 0.92, P ＜0.05). Reverse MR showed that genetically predicted LBP was positively correlated with 6 IDPs (β range from 0.10 to 0.17, P ＜0.05) and negatively correlated with 8 IDPs (β range from −0.15 to −0.10, P ＜0.05). There is a relationship between IDPs and LBP risk. Our findings provide potential strategies for predicting LBP risk at the brain-imaging level.http://www.sciencedirect.com/science/article/pii/S0361923025002527Low back painBrain imaging-derived phenotypesCausal effectsMendelian randomization |
| spellingShingle | Xiao-Yan Xie Jian-Wei Lin Jia-Yu Fang Zhuo-Chen Chen Peng-Cheng Li Xiao-Yan Huang Ming-Yan Guo Li-Ling Lin Ming-Hui Cao Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain Brain Research Bulletin Low back pain Brain imaging-derived phenotypes Causal effects Mendelian randomization |
| title | Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain |
| title_full | Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain |
| title_fullStr | Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain |
| title_full_unstemmed | Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain |
| title_short | Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain |
| title_sort | mendelian randomization analyses support causal relationship between brain imaging derived phenotypes and risk of low back pain |
| topic | Low back pain Brain imaging-derived phenotypes Causal effects Mendelian randomization |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025002527 |
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