Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis
Abstract The present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long‐term mental health outcomes. One hundred and eighty‐six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanni...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411070 |
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| author | Yuening Jin Dang Zheng Ruolei Gu Qingchen Fan Martin Dietz Changshuo Wang Xinying Li Jie Chen Yuanyuan Hu Yuan Zhou |
| author_facet | Yuening Jin Dang Zheng Ruolei Gu Qingchen Fan Martin Dietz Changshuo Wang Xinying Li Jie Chen Yuanyuan Hu Yuan Zhou |
| author_sort | Yuening Jin |
| collection | DOAJ |
| description | Abstract The present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long‐term mental health outcomes. One hundred and eighty‐six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanning in their early adulthood (Study‐1) and are measured on depressive symptoms eight years later (Study‐2). With computational modeling, the process of norm adaptation is differentiated from that of fairness valuation in UG. The two processes both have moderate levels of heritability. The anterior insula has a significant phenotypic correlation, whereas the Supplementary Motor Area/Medial Frontal Gyrus (SMA/mSFG) shows both a significant phenotypic correlation and a shared genetic influence with the learning rate, an index for norm adaptation. The dopaminergic DRD2 polymorphisms correlate with both the learning rate and the SMA/mSFG encoding of prediction error, constituting of their common genetic basis. Regional gene expression analysis reveals the high expression of dopamine‐related genes in the SMA/mSFG. Moreover, the learning rate can predict depressive symptom severity eight years later, with the DRD2 polymorphisms constituting their shared genetic basis. This suggests that heritability is a non‐negligible driving force behind norm adaptation, which facilitates the learning of social norms in changing environments and preserves long‐term mental health. |
| format | Article |
| id | doaj-art-2ddcc4ce141b4fcaa2643d3b4df9a8c9 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-2ddcc4ce141b4fcaa2643d3b4df9a8c92025-08-20T03:24:44ZengWileyAdvanced Science2198-38442025-03-01129n/an/a10.1002/advs.202411070Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural BasisYuening Jin0Dang Zheng1Ruolei Gu2Qingchen Fan3Martin Dietz4Changshuo Wang5Xinying Li6Jie Chen7Yuanyuan Hu8Yuan Zhou9CAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaCAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaCAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaCAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaCenter of Functionally Integrative Neuroscience Institute of Clinical Medicine Aarhus University Universitetsbyen 3 Aarhus 8000 DenmarkCAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaDepartment of Psychology University of Chinese Academy of Sciences Beijing 100049 ChinaDepartment of Psychology University of Chinese Academy of Sciences Beijing 100049 ChinaCAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaCAS Key Laboratory of Behavioral Science Institute of Psychology Chinese Academy of Sciences Beijing 100101 ChinaAbstract The present research uncovers the shared genetic underpinnings of fairness norm adaptation capability, its neural correlates, and long‐term mental health outcomes. One hundred and eighty‐six twins are recruited and played as responders in the Ultimatum Game (UG) while undergoing fMRI scanning in their early adulthood (Study‐1) and are measured on depressive symptoms eight years later (Study‐2). With computational modeling, the process of norm adaptation is differentiated from that of fairness valuation in UG. The two processes both have moderate levels of heritability. The anterior insula has a significant phenotypic correlation, whereas the Supplementary Motor Area/Medial Frontal Gyrus (SMA/mSFG) shows both a significant phenotypic correlation and a shared genetic influence with the learning rate, an index for norm adaptation. The dopaminergic DRD2 polymorphisms correlate with both the learning rate and the SMA/mSFG encoding of prediction error, constituting of their common genetic basis. Regional gene expression analysis reveals the high expression of dopamine‐related genes in the SMA/mSFG. Moreover, the learning rate can predict depressive symptom severity eight years later, with the DRD2 polymorphisms constituting their shared genetic basis. This suggests that heritability is a non‐negligible driving force behind norm adaptation, which facilitates the learning of social norms in changing environments and preserves long‐term mental health.https://doi.org/10.1002/advs.202411070anterior insulafairness norm adaptationgeneticsprediction error encodingsupplementary motor areatwin studies |
| spellingShingle | Yuening Jin Dang Zheng Ruolei Gu Qingchen Fan Martin Dietz Changshuo Wang Xinying Li Jie Chen Yuanyuan Hu Yuan Zhou Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis Advanced Science anterior insula fairness norm adaptation genetics prediction error encoding supplementary motor area twin studies |
| title | Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis |
| title_full | Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis |
| title_fullStr | Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis |
| title_full_unstemmed | Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis |
| title_short | Substantial Heritability Underlies Fairness Norm Adaptation Capability and its Neural Basis |
| title_sort | substantial heritability underlies fairness norm adaptation capability and its neural basis |
| topic | anterior insula fairness norm adaptation genetics prediction error encoding supplementary motor area twin studies |
| url | https://doi.org/10.1002/advs.202411070 |
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