Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection

Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection

Abstract The global spread, frequent antigenic changes, and pandemic potential of clade 2.3.4.4b highly pathogenic avian influenza H5N1 underscore the urgent need for robust cross-protective vaccines. Here, we developed a clade 2.3.4.4b H5N1 whole inactivated virus (WIV) vaccine strain with improved...

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Bibliographic Details
Main Authors: Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Seung-Ji Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Kang-Seuk Choi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Virology Journal
Subjects:
Highly pathogenic avian influenza virus
Heat stability
Whole inactivated virus vaccine
Binary ethylenimine
Intranasal administration
Cross-protection
Online Access:https://doi.org/10.1186/s12985-025-02760-4
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