Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas
Objectives:An elevated platelet count is considered an independent prediction of survey in glioblastoma and various other intracranial entities. Activity of the tumor microcirculation resulting in platelet activation and release of several cytokines and factors from activated platelets has been sugg...
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Galenos Publishing House
2019-08-01
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| Series: | Ankara Üniversitesi Tıp Fakültesi Mecmuas |
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| author | Tolga Turan Dündar |
| author_facet | Tolga Turan Dündar |
| author_sort | Tolga Turan Dündar |
| collection | DOAJ |
| description | Objectives:An elevated platelet count is considered an independent prediction of survey in glioblastoma and various other intracranial entities. Activity of the tumor microcirculation resulting in platelet activation and release of several cytokines and factors from activated platelets has been suggested to play an active role in neuro-inflammation. Ki-67 index and mitotic activity are markers which could be showed proliferation in the glial tumor. High Ki-67 expression and mitosis rate of high grade glial tumors have been more aggressive clinical progression, poor prognosis, more vascular invasion than low. Recently, Mean Platelet Volume (MPV) to platelet count (PLT) ratio has become a trend indicator to anticipate the outcome of a patient suffering from intracranial pathologies. The study aims to determine first time whether the comparison of the Volume Index (PVI) as an immune response marker with the Ki-67 and mitotic activity could be used as a prognostic factor in gliablastoma (WHO Grade IV).Materials and Methods:In the retrospective study, we studied 65 patients diagnosed with glioblastoma who had inclusion and exclusion criteria. The correlation between PVI, Ki-67 and mitotic activity was examined all cases after pathologically diagnosed, by the routine processes of the pathological preparates. PVI was calculated from pre-operative first complete blood count (CBC) and was defined as MPV value (fL)x100/PLT (per 1000). The Kolmogorov-Smirnov test and Spearman’s correlation coefficient was used in the analysis of the interrelationship.Results:The correlation between the PVI, Ki-67 and mitotic index was found to be leak statistically correlation.Conclusion:It was determined that PVI is decreased, Ki-67 immunoreactivity and mitotic index are increased. The PVI may be used as a prognostic, predictive factor for glioblastoma. Nevertheless, further studies concerning the prognosis of glioblastoma are needed to confirm this hypothesis. |
| format | Article |
| id | doaj-art-2dd64d05583c44e591045e9133013fa9 |
| institution | Kabale University |
| issn | 1307-5608 1307-5608 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Ankara Üniversitesi Tıp Fakültesi Mecmuas |
| spelling | doaj-art-2dd64d05583c44e591045e9133013fa92025-08-20T03:55:06ZengGalenos Publishing HouseAnkara Üniversitesi Tıp Fakültesi Mecmuas1307-56081307-56082019-08-0172222222610.4274/atfm.galenos.2019.9358413049054Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in GliablastomasTolga Turan Dündar0 Bezmialem Vakıf Üniversitesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, İstanbul, Türkiye Objectives:An elevated platelet count is considered an independent prediction of survey in glioblastoma and various other intracranial entities. Activity of the tumor microcirculation resulting in platelet activation and release of several cytokines and factors from activated platelets has been suggested to play an active role in neuro-inflammation. Ki-67 index and mitotic activity are markers which could be showed proliferation in the glial tumor. High Ki-67 expression and mitosis rate of high grade glial tumors have been more aggressive clinical progression, poor prognosis, more vascular invasion than low. Recently, Mean Platelet Volume (MPV) to platelet count (PLT) ratio has become a trend indicator to anticipate the outcome of a patient suffering from intracranial pathologies. The study aims to determine first time whether the comparison of the Volume Index (PVI) as an immune response marker with the Ki-67 and mitotic activity could be used as a prognostic factor in gliablastoma (WHO Grade IV).Materials and Methods:In the retrospective study, we studied 65 patients diagnosed with glioblastoma who had inclusion and exclusion criteria. The correlation between PVI, Ki-67 and mitotic activity was examined all cases after pathologically diagnosed, by the routine processes of the pathological preparates. PVI was calculated from pre-operative first complete blood count (CBC) and was defined as MPV value (fL)x100/PLT (per 1000). The Kolmogorov-Smirnov test and Spearman’s correlation coefficient was used in the analysis of the interrelationship.Results:The correlation between the PVI, Ki-67 and mitotic index was found to be leak statistically correlation.Conclusion:It was determined that PVI is decreased, Ki-67 immunoreactivity and mitotic index are increased. The PVI may be used as a prognostic, predictive factor for glioblastoma. Nevertheless, further studies concerning the prognosis of glioblastoma are needed to confirm this hypothesis. http://ankaratipfakultesimecmuasi.net/archives/archive-detail/article-preview/comparasion-between-mitotic-activity-ki-67-ndex-an/30441 GlioblastomaGBMPlateletsMean Platelet VolumePlatelet Volume IndexPVI |
| spellingShingle | Tolga Turan Dündar Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas Ankara Üniversitesi Tıp Fakültesi Mecmuas Glioblastoma GBM Platelets Mean Platelet Volume Platelet Volume Index PVI |
| title | Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas |
| title_full | Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas |
| title_fullStr | Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas |
| title_full_unstemmed | Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas |
| title_short | Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas |
| title_sort | comparasion between mitotic activity ki 67 index and platelet volume index as a prognostic marker in gliablastomas |
| topic | Glioblastoma GBM Platelets Mean Platelet Volume Platelet Volume Index PVI |
| url |
http://ankaratipfakultesimecmuasi.net/archives/archive-detail/article-preview/comparasion-between-mitotic-activity-ki-67-ndex-an/30441
|
| work_keys_str_mv | AT tolgaturandundar comparasionbetweenmitoticactivityki67indexandplateletvolumeindexasaprognosticmarkeringliablastomas |